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    Ahcyl1 S-adenosylhomocysteine hydrolase-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 229709, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ahcyl1provided by MGI
    Official Full Name
    S-adenosylhomocysteine hydrolase-like 1provided by MGI
    Primary source
    MGI:MGI:2385184
    See related
    Ensembl:ENSMUSG00000027893 AllianceGenome:MGI:2385184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DCAL; Irbit; Ahcy-rs3; 1110034F20Rik
    Summary
    Enables enzyme regulator activity. Involved in epithelial fluid transport. Acts upstream of or within several processes, including protein export from nucleus; regulation of mRNA 3'-end processing; and regulation of monoatomic ion transport. Located in cytosol and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human AHCYL1 (adenosylhomocysteinase like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 80.6), cortex adult (RPKM 64.9) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ahcyl1 in Genome Data Viewer
    Location:
    3 F2.3; 3 46.83 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107570436..107603876, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107663120..107696560, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene striatin interacting protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:107434637-107434746 Neighboring gene predicted gene 10961 Neighboring gene predicted gene, 52629 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:107499306-107499489 Neighboring gene predicted gene, 40121 Neighboring gene STARR-seq mESC enhancer starr_08670 Neighboring gene colony stimulating factor 1 (macrophage) Neighboring gene uncharacterized LOC118568636

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables adenosylhomocysteinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT enables adenosylhomocysteinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in angiotensin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiotensin-activated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in epithelial fluid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrion-endoplasmic reticulum membrane tethering ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion-endoplasmic reticulum membrane tethering ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of sodium ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of mRNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of monoatomic anion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of monoatomic ion transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of monoatomic ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondria-associated endoplasmic reticulum membrane contact site ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    S-adenosylhomocysteine hydrolase-like protein 1
    Names
    IP3R binding protein released with inositol 1,4,5-trisphosphate
    S-adenosyl-L-homocysteine hydrolase 2
    S-adenosylhomocysteine hydrolase, related sequence 3
    adoHcyase 2
    putative adenosylhomocysteinase 2
    NP_001344039.1
    NP_001344040.1
    NP_001344041.1
    NP_001344042.1
    NP_663517.2
    XP_030108450.1
    XP_030108451.1
    XP_030108452.1
    XP_030108453.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357110.1NP_001344039.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122902, AC140786, BQ176498
      UniProtKB/TrEMBL
      Q80TQ9
      Conserved Domains (1) summary
      smart00996
      Location:59482
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    2. NM_001357111.1NP_001344040.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122902, AC140786, BQ176498
      Conserved Domains (1) summary
      cl21454
      Location:2312
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. NM_001357112.1NP_001344041.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122902, AC140786, BQ176498
      Conserved Domains (1) summary
      cl21454
      Location:2312
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    4. NM_001357113.1NP_001344042.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122902, AC140786, BQ176498
      Conserved Domains (1) summary
      cl21454
      Location:21288
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    5. NM_145542.4NP_663517.2  S-adenosylhomocysteine hydrolase-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_663517.2

      Status: VALIDATED

      Source sequence(s)
      AB092504, AC122902, AC140786, AK004088, BQ176498, CJ162898
      Consensus CDS
      CCDS38593.1
      UniProtKB/Swiss-Prot
      Q80SW1
      UniProtKB/TrEMBL
      Q80TQ9
      Related
      ENSMUSP00000029490.9, ENSMUST00000029490.15
      Conserved Domains (1) summary
      smart00996
      Location:106529
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      107570436..107603876 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252590.2XP_030108450.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:21288
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. XM_030252592.2XP_030108452.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:21288
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. XM_030252593.2XP_030108453.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:21288
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    4. XM_030252591.2XP_030108451.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:21288
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins