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    RSRC2 arginine and serine rich coiled-coil 2 [ Homo sapiens (human) ]

    Gene ID: 65117, updated on 27-Nov-2024

    Summary

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    Official Symbol
    RSRC2provided by HGNC
    Official Full Name
    arginine and serine rich coiled-coil 2provided by HGNC
    Primary source
    HGNC:HGNC:30559
    See related
    Ensembl:ENSG00000111011 MIM:619996; AllianceGenome:HGNC:30559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables RNA binding activity. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 73.5), testis (RPKM 24.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RSRC2 in Genome Data Viewer
    Location:
    12q24.31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (122503454..122526936, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (122499260..122522407, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (122988001..123011483, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene CAP-Gly domain containing linker protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122885121-122885806 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122885807-122886492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7219 Neighboring gene CLIP1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5015 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:122916171-122916672 Neighboring gene Sharpr-MPRA regulatory region 9757 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:122927953-122928453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7225 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7226 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:122984447-122985138 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:122985139-122985832 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:122985833-122986524 Neighboring gene MPRA-validated peak2019 silencer Neighboring gene zinc finger CCHC-type containing 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7231 Neighboring gene kinetochore associated 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7232 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5018 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:123122624-123123524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7233 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7235 Neighboring gene uncharacterized LOC124903124

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel gene, RSRC2, inhibits cell proliferation and affects survival in esophageal cancer patients. Kurehara H, et al. Int J Oncol, 2007 Feb. PMID 17203224
    2. TRA2A Promoted Paclitaxel Resistance and Tumor Progression in Triple-Negative Breast Cancers via Regulating Alternative Splicing. Liu T, et al. Mol Cancer Ther, 2017 Jul. PMID 28416606
    3. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Rahman S, et al. Mol Cell Biol, 2011 Jul. PMID 21555454, Free PMC Article
    4. KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4. Kumar A, et al. Cell Rep, 2022 May 10. PMID 35545047, Free PMC Article
    5. Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners. Gallardo-Vara E, et al. Cells, 2019 Sep 13. PMID 31540324, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11021

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arginine/serine-rich coiled-coil protein 2
    Names
    arginine/serine-rich coiled-coil 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023012.6 → NP_075388.2  arginine/serine-rich coiled-coil protein 2

      See identical proteins and their annotated locations for NP_075388.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the shortest transcript but encodes a functional protein.
      Source sequence(s)
      AB212664, AC127002
      Consensus CDS
      CCDS31920.1
      UniProtKB/Swiss-Prot
      Q6N040, Q6NW16, Q7L4I2, Q9H864
      Related
      ENSP00000330188.6, ENST00000331738.12
      Conserved Domains (1) summary
      pfam15477
      Location:354 → 423
      SMAP; Small acidic protein family

    RNA

    1. NR_036434.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an additional exon in the CDS compared to variant 1. The exon includes a premature stop codon, so this variant is a nonsense-mediated mRNA decay candidate and does not make a functional protein.
      Source sequence(s)
      AC127002, AK094465, BC008684

    2. NR_036435.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional exon and an additional segment in the CDS compared to variant 1. The exon includes a premature stop codon, so this variant is a nonsense-mediated mRNA decay candidate and does not make a functional protein.
      Source sequence(s)
      AC127002, DB081070

    3. NR_036436.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has an additional segment in the CDS compared to variant 1. The segment includes a premature stop codon, so this variant is a nonsense-mediated mRNA decay candidate and does not make a functional protein.
      Source sequence(s)
      AB212664, AC127002, BX647884

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      122503454..122526936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017019830.3 → XP_016875319.1  arginine/serine-rich coiled-coil protein 2 isoform X3

    2. XM_011538688.3 → XP_011536990.1  arginine/serine-rich coiled-coil protein 2 isoform X2

      Conserved Domains (1) summary
      pfam15477
      Location:342 → 394
      SMAP; Small acidic protein family

    3. XM_005253601.3 → XP_005253658.1  arginine/serine-rich coiled-coil protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005253658.1

      Conserved Domains (1) summary
      pfam15477
      Location:355 → 424
      SMAP; Small acidic protein family

    4. XM_047429371.1 → XP_047285327.1  arginine/serine-rich coiled-coil protein 2 isoform X7

    5. XM_005253602.3 → XP_005253659.1  arginine/serine-rich coiled-coil protein 2 isoform X4

      Conserved Domains (1) summary
      pfam15477
      Location:307 → 376
      SMAP; Small acidic protein family

    6. XM_047429372.1 → XP_047285328.1  arginine/serine-rich coiled-coil protein 2 isoform X8

    7. XM_047429370.1 → XP_047285326.1  arginine/serine-rich coiled-coil protein 2 isoform X6

    8. XM_047429369.1 → XP_047285325.1  arginine/serine-rich coiled-coil protein 2 isoform X5

    9. XM_047429373.1 → XP_047285329.1  arginine/serine-rich coiled-coil protein 2 isoform X9

    RNA

    1. XR_007063114.1 RNA Sequence

    2. XR_007063115.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      122499260..122522407 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372926.1 → XP_054228901.1  arginine/serine-rich coiled-coil protein 2 isoform X3

    2. XM_054372925.1 → XP_054228900.1  arginine/serine-rich coiled-coil protein 2 isoform X2

    3. XM_054372924.1 → XP_054228899.1  arginine/serine-rich coiled-coil protein 2 isoform X1

    4. XM_054372927.1 → XP_054228902.1  arginine/serine-rich coiled-coil protein 2 isoform X4

    5. XM_054372933.1 → XP_054228908.1  arginine/serine-rich coiled-coil protein 2 isoform X11

    6. XM_054372932.1 → XP_054228907.1  arginine/serine-rich coiled-coil protein 2 isoform X10

      UniProtKB/TrEMBL
      B3KMH4

    7. XM_054372930.1 → XP_054228905.1  arginine/serine-rich coiled-coil protein 2 isoform X8

    8. XM_054372929.1 → XP_054228904.1  arginine/serine-rich coiled-coil protein 2 isoform X6

    9. XM_054372928.1 → XP_054228903.1  arginine/serine-rich coiled-coil protein 2 isoform X5

    10. XM_054372931.1 → XP_054228906.1  arginine/serine-rich coiled-coil protein 2 isoform X9

    RNA

    1. XR_008488664.1 RNA Sequence

    2. XR_008488665.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198261.2: Suppressed sequence

      Description
      NM_198261.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_198262.2: Suppressed sequence

      Description
      NM_198262.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7L4I2.1 GenPept UniProtKB/Swiss-Prot:Q7L4I2

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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