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    Cyp12e1 Cytochrome P450 12e1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41272, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp12e1provided by FlyBase
    Official Full Name
    Cytochrome P450 12e1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037817
    Locus tag
    Dmel_CG14680
    See related
    AllianceGenome:FB:FBgn0037817
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    12e1; CG14680; Cyp12e; Cyp12E1; Dmel\CG14680
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp12e1 in Genome Data Viewer
    Location:
    86B4-86B4; 3-49 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10434789..10436704)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6260511..6262426)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rrp46 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44939 Neighboring gene long non-coding RNA:CR44955

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic incompatibilities are widespread within species. Corbett-Detig RB, et al. Nature, 2013 Dec 5. PMID 24196712, Free PMC Article
    2. Evolution of supergene families associated with insecticide resistance. Ranson H, et al. Science, 2002 Oct 4. PMID 12364796
    3. Male specific expression of a cytochrome P450 (Cyp312a1) in Drosophila melanogaster. Kasai S, et al. Biochem Biophys Res Commun, 2003 Jan 24. PMID 12559957
    4. Identifying new players in structural synaptic plasticity through dArc1 interrogation. Xiao C, et al. iScience, 2023 Nov 17. PMID 37876812, Free PMC Article
    5. Functional roles for redox genes in ethanol sensitivity in Drosophila. Awofala AA, et al. Funct Integr Genomics, 2012 Jun. PMID 22430022

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 12e1
    Names
    CG14680-PC
    Cyp12e1-PC
    NP_650003.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10434789..10436704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141746.4 → NP_650003.4  cytochrome P450 12e1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650003.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4V453, Q4V470, Q8INL9, Q9VGZ0
      Conserved Domains (1) summary
      cl12078
      Location:63 → 517
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGZ0.4 Q9VGZ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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