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    GIC2 Gic2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851904, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GIC2
    Official Full Name
    Gic2p
    Primary source
    SGD:S000002717
    Locus tag
    YDR309C
    See related
    AllianceGenome:SGD:S000002717; FungiDB:YDR309C; VEuPathDB:YDR309C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphatidylinositol-4,5-bisphosphate binding activity and small GTPase binding activity. Involved in several processes, including Cdc42 protein signal transduction; positive regulation of formin-nucleated actin cable assembly; and regulation of exit from mitosis. Located in several cellular components, including cellular bud tip; incipient cellular bud site; and mating projection tip. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GIC2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1079048..1080199, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative dolichyl-phosphate-mannose--protein mannosyltransferase Neighboring gene Srb7p Neighboring gene Sum1p Neighboring gene TFIIH/NER complex subunit TFB1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of Gic2 localization and function by phosphatidylinositol 4,5-bisphosphate during the establishment of cell polarity in budding yeast. Orlando K, et al. J Biol Chem, 2008 May 23. PMID 18387956, Free PMC Article
    2. Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p. Chen H, et al. Mol Biol Cell, 2012 Oct. PMID 22918946, Free PMC Article
    3. A role for Gic1 and Gic2 in Cdc42 polarization at elevated temperature. Daniels CN, et al. PLoS One, 2018. PMID 30566437, Free PMC Article
    4. The Cdc42 effectors Gic1 and Gic2 regulate polarized post-Golgi secretion. Liu Y, et al. Cell Biosci, 2019. PMID 30988896, Free PMC Article
    5. Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast. Brown JL, et al. Genes Dev, 1997 Nov 15. PMID 9367980, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In yeast cells, Cdc42 polarization involves a positive feedback loop in which effectors called p21-activated kinases (PAKs) act to recruit a Cdc42-directed guanine nucleotide exchange factor (GEF), generating more GTP-Cdc42 in areas that already have GTP-Cdc42. The GTPase-interacting components (GICs) Gic1 and Gic2 are also Cdc42 effectors, and have been implicated in regulation of the actin and septin cytoskeleton.
      Title: A role for Gic1 and Gic2 in Cdc42 polarization at elevated temperature.
    2. A novel regulatory input to Bni1p acting through the Cdc42p effector, Gic2p.
      Title: Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p.
    3. phosphatidylinositol 4,5-bisphosphate and Cdc42 act in concert to regulate polarized localization and function of Gic2 during polarized cell growth in the budding yeast
      Title: Regulation of Gic2 localization and function by phosphatidylinositol 4,5-bisphosphate during the establishment of cell polarity in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Cdc42 protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of formin-nucleated actin cable assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septin ring organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in septin ring organization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Gic2p
    NP_010595.1
    • Rho-family GTPase interacting protein and Cdc42p effector; required with Gic1p for cell polarity establishment and initiation of budding; involved in recruitment of septins to the presumptive bud site; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region; gic1 gic2 double mutants are defective for polarizing Cdc42p at elevated temperature, so may function both up- and downstream of Cdc42p; regulates mitotic exit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1079048..1080199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180617.1 → NP_010595.1  TPA: Gic2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010595.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VST8, Q06648
      UniProtKB/TrEMBL
      A6ZYQ7, B3LFY7, B5VGI7, C7GQV9, C8Z5M0, G2WB47, N1P746
      Conserved Domains (1) summary
      cd00132
      Location:132 → 169
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06648.1

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