DUG1 metallodipeptidase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: DUG1
Official Full Name: metallodipeptidase
Primary source: SGD:S000001940
Locus tag: YFR044C
See related: AllianceGenome:SGD:S000001940; FungiDB:YFR044C; VEuPathDB:YFR044C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables metallodipeptidase activity and omega peptidase activity. Involved in glutathione catabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in glomerulonephritis. Orthologous to several human genes including CNDP2 (carnosine dipeptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See DUG1 in Genome Data Viewer

Location:: chromosome: VI

Exon count:: 1

Sequence:: Chromosome: VI; NC_001138.5 (239992..241437, complement)

Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of cDNAs is a promising approach to engineer S. cerevisiae metabolism; here DUG1 overexpression lead to enhance growth of non-ethanol producing S. cerevisiae strains lacking pyruvate decarboxylases.
Title: Expression of Saccharomyces cerevisiae cDNAs to enhance the growth of non-ethanol-producing S. cerevisiae strains lacking pyruvate decarboxylases.
Structural similarity between the Dug1p-peptide complex and the bestatin-bound complex of CN2 suggests that the Dug1p-peptide structure can be used as a template for designing natural peptide inhibitors.
Title: Molecular basis of peptide recognition in metallopeptidase Dug1p from Saccharomyces cerevisiae.
The Dug1p family represents a novel class of Cys-Gly dipeptidases.
Title: Dug1p Is a Cys-Gly peptidase of the gamma-glutamyl cycle of Saccharomyces cerevisiae and represents a novel family of Cys-Gly peptidases.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables dipeptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallodipeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metallodipeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallodipeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables omega peptidase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in glutathione catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: metallodipeptidase

NP_116702.1

Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); human homolog CNDP2 can complement yeast dug1 mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001138.5 Reference assembly

Range

239992..241437 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180009.1 → NP_116702.1 TPA: metallodipeptidase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_116702.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTS7, P43616

UniProtKB/TrEMBL

A7A284, B3LUQ5, B5VI69, C7GYE8, C8Z7X9, G2WDI5, N1P4R7

Conserved Domains (1) summary

cd05676
Location:8 → 477

M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase