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    HIP1 histidine permease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853104, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HIP1
    Official Full Name
    histidine permease
    Primary source
    SGD:S000003423
    Locus tag
    YGR191W
    See related
    AllianceGenome:SGD:S000003423; FungiDB:YGR191W; VEuPathDB:YGR191W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables high-affinity L-histidine transmembrane transporter activity. Involved in histidine transport and manganese ion transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HIP1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (880420..882231)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene transglycosylase Neighboring gene tRNA-Trp Neighboring gene glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3 Neighboring gene Pdx1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The histidine permease gene (HIP1) of Saccharomyces cerevisiae. Tanaka J, et al. Gene, 1985. PMID 3905514
    2. Regulation of histidine uptake by specific feedback inhibition of two histidine permeases in Saccharomyces cerevisiae. Crabeel M, et al. Eur J Biochem, 1970 May 1. PMID 5447432
    3. Involvement of histidine permease (Hip1p) in manganese transport in Saccharomyces cerevisiae. Farcasanu IC, et al. Mol Gen Genet, 1998 Sep. PMID 9790586
    4. [Ubiquitination regulation of histidine transporter Hip1p on histidine utilization in Saccharomyces cerevisiae]. Zhang P, et al. Wei Sheng Wu Xue Bao, 2016 Oct 4. PMID 29741343
    5. TAT1 encodes a low-affinity histidine transporter in Saccharomyces cerevisiae. Bajmoczi M, et al. Biochem Biophys Res Commun, 1998 Feb 4. PMID 9473505

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables high-affinity L-histidine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-histidine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in histidine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in manganese ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histidine permease
    NP_011707.1
    • High-affinity histidine permease; also involved in the transport of manganese ions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      880420..882231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181320.1 → NP_011707.1  TPA: histidine permease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011707.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUX3, P06775
      UniProtKB/TrEMBL
      A6ZUK1, B5VJD3, G2WER9, N1P484
      Conserved Domains (1) summary
      TIGR00913
      Location:88 → 567
      2A0310; amino acid permease (yeast)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06775.2

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