SLN1 histidine kinase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SLN1
Official Full Name: histidine kinase
Primary source: SGD:S000001409
Locus tag: YIL147C
See related: AllianceGenome:SGD:S000001409; FungiDB:YIL147C; VEuPathDB:YIL147C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: YPD2
Summary: Enables histidine phosphotransfer kinase activity; osmosensor activity; and protein histidine kinase activity. Involved in osmosensory signaling via phosphorelay pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SLN1 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (69791..73453, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The yeast two-component SLN1 branch of the HOG pathway and the scaffolding activity of Pbs2 modulate the response to endoplasmic reticulum stress induced by tunicamycin.
Title: The yeast two-component SLN1 branch of the HOG pathway and the scaffolding activity of Pbs2 modulate the response to endoplasmic reticulum stress induced by tunicamycin.
network structure of the Sln1-Ypd1-Ssk1 three-component phospho-relay prevents unintended activation of the HOG MAPK pathway in Saccharomyces cerevisiae
Title: Robust network structure of the Sln1-Ypd1-Ssk1 three-component phospho-relay prevents unintended activation of the HOG MAPK pathway in Saccharomyces cerevisiae.
Increasing osmolyte concentrations negatively affect the YPD1 interaction with SSK1, thereby facilitating dephosphorylation of SSK1 and activating the HOG1 MAP kinase cascade.
Title: Effects of osmolytes on the SLN1-YPD1-SSK1 phosphorelay system from Saccharomyces cerevisiae.
Modulation of yeast Sln1 kinase activity by the CCW12 cell wall protein.
Title: Modulation of yeast Sln1 kinase activity by the CCW12 cell wall protein.
Mutation of the protein conferring resistance to the pradimicin antifungal.
Title: Pradimicin resistance of yeast is caused by a mutation of the putative N-glycosylation sites of osmosensor protein Sln1.
Mog1p may play a role in SLN1-SKN7 signal transduction, Skn7 binding and activation of osmotic response genes
Title: Role for the Ran binding protein, Mog1p, in Saccharomyces cerevisiae SLN1-SKN7 signal transduction.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histidine phosphotransfer kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histidine phosphotransfer kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables histidine phosphotransfer kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables osmosensor activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphorelay sensor kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphorelay sensor kinase activity	IEA Inferred from Electronic Annotation more info
enables protein histidine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in osmosensory signaling via phosphorelay pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphorelay signal transduction system	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphorelay signal transduction system	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histidine kinase

NP_012119.1

EC 2.7.13.3

Transmembrane histidine phosphotransfer kinase and osmosensor; regulates MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

69791..73453 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179495.1 → NP_012119.1 TPA: histidine kinase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012119.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVE0, P39928

UniProtKB/TrEMBL

B3LTZ4, C7GUR4

Conserved Domains (2) summary

PRK10935
Location:518 → 553

PRK10935; nitrate/nitrite two-component system sensor histidine kinase NarQ

PRK11107
Location:567 → 1210

PRK11107; hybrid sensory histidine kinase BarA; Provisional