CDC11 septin CDC11 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CDC11
Official Full Name: septin CDC11
Primary source: SGD:S000003837
Locus tag: YJR076C
See related: AllianceGenome:SGD:S000003837; FungiDB:YJR076C; VEuPathDB:YJR076C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PSL9
Summary: Enables GTP binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. A structural constituent of cytoskeleton. Involved in mitotic cytokinesis; positive regulation of protein phosphorylation; and protein localization to bud neck. Located in several cellular components, including cytoskeleton; mating projection base; and prospore membrane. Part of septin complex. Orthologous to human SEPTIN5 (septin 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CDC11 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (575354..576601, complement)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reconstructed evolutionary history of the yeast septins Cdc11 and Shs1.
Title: Reconstructed evolutionary history of the yeast septins Cdc11 and Shs1.
Septin complexes have symmetric termini, even when both Shs1 and Cdc11 are coexpressed. The relative proportion of Cdc11/Shs1 septin complexes controls the biophysical properties of filaments and influences the rate of annealing, fragmentation, and filament flexibility.
Title: Control of septin filament flexibility and bundling by subunit composition and nucleotide interactions.
The authors found that the interaction of Bni5 with the terminal subunit (Cdc11) at the junctions between adjacent hetero-octamers in paired filaments is highly cooperative.
Title: Effects of Bni5 Binding on Septin Filament Organization.
From the nucleotide-free structure some interesting conclusions about the nucleotide binding properties of Cdc11 can be drawn; especially when aligning the structure with the structure of GDP bound Sept2
Title: Crystal structure of Cdc11, a septin subunit from Saccharomyces cerevisiae.
Important function of the CTEs of Cdc11 and Shs1 is optimizing recruitment of Bni5 and thereby ensuring efficient localization at the bud neck of Myo1, the type II myosin of the actomyosin contractile ring.
Title: The Carboxy-Terminal Tails of Septins Cdc11 and Shs1 Recruit Myosin-II Binding Factor Bni5 to the Bud Neck in Saccharomyces cerevisiae.
The sole portion of Shs1 essential for its function is predicted coiled-coil-forming segment in its C-terminal extension (CTE). CTE of Cdc11 shares this function. This role for the CTEs of Cdc11 and Shs1 is distinct from that of the CTEs of Cdc3 and Cdc12
Title: Comprehensive Genetic Analysis of Paralogous Terminal Septin Subunits Shs1 and Cdc11 in Saccharomyces cerevisiae.
It was shown that Shs1 substitutes for Cdc11, resulting in octameric rods that do not polymerize into filaments but associate laterally, forming curved bundles that close into rings.
Title: Subunit-dependent modulation of septin assembly: budding yeast septin Shs1 promotes ring and gauze formation.
Bni5 phosphorylation is important for interaction with septin component Cdc11 and for timely delocalization from septin filament at late mitosis.
Title: Phosphorylation-dependent septin interaction of Bni5 is important for cytokinesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4-phosphate binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol-5-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-5-phosphate binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of cytoskeleton	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actomyosin contractile ring assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular bud neck septin ring organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton-dependent cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in division septum assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to bud neck	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to bud neck	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in ascospore wall	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell division site	IBA Inferred from Biological aspect of Ancestor more info
located_in cellular bud neck	HDA more info	PubMed
located_in cellular bud neck	IEA Inferred from Electronic Annotation more info
located_in cellular bud neck septin ring	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mating projection base	IDA Inferred from Direct Assay more info	PubMed
located_in mating projection tip	HDA more info	PubMed
located_in meiotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in prospore membrane	HDA more info	PubMed
located_in prospore membrane	IDA Inferred from Direct Assay more info	PubMed
part_of septin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of septin complex	IDA Inferred from Direct Assay more info	PubMed
part_of septin complex	IEA Inferred from Electronic Annotation more info
part_of septin complex	IPI Inferred from Physical Interaction more info	PubMed
located_in septin filament array	IDA Inferred from Direct Assay more info	PubMed
is_active_in septin ring	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle microtubule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: septin CDC11

NP_012610.1

Component of the septin ring that is required for cytokinesis; present at the ends of rod-like septin hetero-oligomers; C-terminal extension is important for recruitment of Bni5p to the mother-bud neck, which in turn is required for Myo1p recruitment and cytokinesis; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

575354..576601 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181734.1 → NP_012610.1 TPA: septin CDC11 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012610.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWP6, P32458

UniProtKB/TrEMBL

A6ZQ34, B3LQG2, B5VLM8, C7GMC8, C8ZBM3, G2WH80, N1P053

Conserved Domains (1) summary

COG5019
Location:5 → 413

CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]