RPL10 ribosomal 60S subunit protein L10 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: RPL10
Official Full Name: ribosomal 60S subunit protein L10
Primary source: SGD:S000004065
Locus tag: YLR075W
See related: AllianceGenome:SGD:S000004065; FungiDB:YLR075W; VEuPathDB:YLR075W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GRC5; QSR1
Summary: Predicted to be a structural constituent of ribosome. Involved in ribosomal large subunit assembly and translational termination. Part of cytosolic large ribosomal subunit. Used to study T-cell acute lymphoblastic leukemia; autistic disorder; spondyloepiphyseal dysplasia congenita; and syndromic X-linked intellectual disability Najm type. Human ortholog(s) of this gene implicated in autistic disorder; spermatogenic failure 63; and syndromic X-linked mental retardation 35. Orthologous to human RPL10 (ribosomal protein L10) and RPL10L (ribosomal protein L10 like). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See RPL10 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (282927..283592)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We determine structures of six intermediates in late nuclear and cytoplasmic maturation of the ribosomal large subunit that reveal a tightly-choreographed sequence of protein and RNA rearrangements controlling the insertion of Rpl10.
Title: Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome.
The T-ALL related rpl10-R98S mutation blocks 60S biogenesis by a mechanism distinct from other rpl10 mutations. The rpl10-R98S mutant is suppressed by mutations in NMD3 and in TIF6.
Title: The T-cell leukemia related rpl10-R98S mutant traps the 60S export adapter Nmd3 in the ribosomal P site in yeast.
mutant Rpl10 proteins were engineered to be unable to bind to the ribosome accumulated in the nucleus
Title: Mutational analysis of the ribosomal protein Rpl10 from yeast.
correct loading of Rpl10p into 60S subunits is required for the release of Nmd3p from subunits by Lsg1p
Title: Release of the export adapter, Nmd3p, from the 60S ribosomal subunit requires Rpl10p and the cytoplasmic GTPase Lsg1p.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IC Inferred by Curator more info	PubMed
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IC Inferred by Curator more info	PubMed
involved_in ribosomal large subunit assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational termination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: ribosomal 60S subunit protein L10

NP_013176.1

Ribosomal 60S subunit protein L10; homologous to mammalian ribosomal protein L10 and bacterial L16; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; protein abundance increases under DNA replication stress; mutations in human homolog implicated in T-cell acute lymphoblastic leukemia and also autism spectrum disorders (ASD); human RPL10 can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

282927..283592

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181962.1 → NP_013176.1 TPA: ribosomal 60S subunit protein L10 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013176.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VY76, P41805

UniProtKB/TrEMBL

A7A0Y0, B3LT44, C7GQQ0, C8ZD46, G2WIR7, N1NZI6

Conserved Domains (1) summary

PTZ00173
Location:1 → 206

PTZ00173; 60S ribosomal protein L10; Provisional