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    PHR1 deoxyribodipyrimidine photo-lyase PHR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854568, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PHR1
    Official Full Name
    deoxyribodipyrimidine photo-lyase PHR1
    Primary source
    SGD:S000005913
    Locus tag
    YOR386W
    See related
    AllianceGenome:SGD:S000005913; FungiDB:YOR386W; VEuPathDB:YOR386W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables deoxyribodipyrimidine photo-lyase activity and mRNA binding activity. Predicted to be involved in circadian regulation of gene expression and entrainment of circadian clock by photoperiod. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in delayed sleep phase syndrome. Orthologous to human CRY1 (cryptochrome circadian regulator 1) and CRY2 (cryptochrome circadian regulator 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PHR1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (1066839..1068536)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative ferric-chelate reductase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene formate dehydrogenase (NAD+)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast DNA photolyase: molecular weight, subunit structure, and reconstruction of active enzyme from its subunits. Boatwright DT, et al. Biochemistry, 1975 Dec 16. PMID 1103968
    2. Sequence of the Saccharomyces cerevisiae PHR1 gene and homology of the PHR1 photolyase to E. coli photolyase. Sancar GB. Nucleic Acids Res, 1985 Nov 25. PMID 3906569, Free PMC Article
    3. Cloning and mapping of Saccharomyces cerevisiae photoreactivation gene PHR1. Schild D, et al. Mol Cell Biol, 1984 Sep. PMID 6092943, Free PMC Article
    4. Photorepair of ultraviolet-induced petite mutational damage in Saccharomyces cerevisiae requires the product of the PHR1 gene. Green G, et al. J Bacteriol, 1980 Nov. PMID 7000754, Free PMC Article
    5. Promoter elements of the PHR1 gene of Saccharomyces cerevisiae and their roles in the response to DNA damage. Sancar GB, et al. Nucleic Acids Res, 1995 Nov 11. PMID 7501452, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyribodipyrimidine photo-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyribodipyrimidine photo-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deoxyribodipyrimidine photo-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables organic cyclic compound binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in circadian regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in entrainment of circadian clock by photoperiod IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in photoreactive repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    deoxyribodipyrimidine photo-lyase PHR1
    NP_015031.1
    • DNA photolyase involved in photoreactivation; repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      1066839..1068536
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183806.1 → NP_015031.1  TPA: deoxyribodipyrimidine photo-lyase PHR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015031.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W379, P05066
      UniProtKB/TrEMBL
      A6ZPL4, B3LK40, B5VSQ7, C7GVG0, C8ZHD4, N1NX40
      Conserved Domains (1) summary
      COG0415
      Location:75 → 565
      PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05066.1

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