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    CQD1 Cqd1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855995, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CQD1
    Official Full Name
    Cqd1p
    Primary source
    SGD:S000006030
    Locus tag
    YPL109C
    See related
    AllianceGenome:SGD:S000006030; FungiDB:YPL109C; VEuPathDB:YPL109C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MCO76
    Summary
    Acts upstream of or within mitochondrion organization and phospholipid homeostasis. Located in mitochondrial inner membrane and mitochondrial inner-outer membrane contact site. Orthologous to human ADCK2 (aarF domain containing kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CQD1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    2
    Sequence:
    Chromosome: XVI; NC_001148.4 (345264..347389, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene arginase Neighboring gene glycerophosphocholine phosphodiesterase Neighboring gene uncharacterized protein Neighboring gene Dpc25p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UbiB proteins regulate cellular CoQ distribution in Saccharomyces cerevisiae. Kemmerer ZA, et al. Nat Commun, 2021 Aug 6. PMID 34362905, Free PMC Article
    2. Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthesis. Stefely JA, et al. Mol Cell, 2015 Jan 8. PMID 25498144, Free PMC Article
    3. The UbiB family member Cqd1 forms a novel membrane contact site in mitochondria. Khosravi S, et al. J Cell Sci, 2023 May 15. PMID 37073556, Free PMC Article
    4. Saccharomyces cerevisiae CSM1 gene encoding a protein influencing chromosome segregation in meiosis I interacts with elements of the DNA replication complex. Wysocka M, et al. Exp Cell Res, 2004 Apr 1. PMID 15023545
    5. A hunt for OM45 synthetic petite interactions in Saccharomyces cerevisiae reveals a role for Miro GTPase Gem1p in cristae structure maintenance. Shvetsova A, et al. Microbiologyopen, 2021 Oct. PMID 34713605, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mitochondrion organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phospholipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner-outer membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cqd1p
    NP_015216.3
    • UbiB protein kinase-like family member; mitochondrial inner membrane protein that interacts with outer membrane proteins Por1p and Om14p to form a MICOS-independent mitochondrial contact site; role in mitochondrial organization; contributes to mitochondrial lipid homeostasis; controls the cellular distribution of coenzyme Q (CoQ); contains a potential mitochondrial targeting sequence and predicted transmembrane domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      345264..347389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183923.1 → NP_015216.3  TPA: Cqd1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015216.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3Q8, Q02981
      UniProtKB/TrEMBL
      A6ZWE2, B3LKW4, C8ZIS1, G2WP72
      Conserved Domains (1) summary
      cd13971
      Location:200 → 538
      ADCK2-like; aarF domain containing kinase 2 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02981.2

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