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    RPL43A ribosomal 60S subunit protein L43A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856156, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPL43A
    Official Full Name
    ribosomal 60S subunit protein L43A
    Primary source
    SGD:S000006247
    Locus tag
    YPR043W
    See related
    AllianceGenome:SGD:S000006247; FungiDB:YPR043W; VEuPathDB:YPR043W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable large ribosomal subunit rRNA binding activity. Predicted to be involved in cytoplasmic translation. Part of cytosolic large ribosomal subunit. Orthologous to several human genes including RPL37A (ribosomal protein L37a). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPL43A in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    2
    Sequence:
    Chromosome: XVI; NC_001148.4 (654166..654847)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene translation initiation factor eIF5 Neighboring gene Puf2p Neighboring gene Thp3p Neighboring gene Mcm16p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of three adjacent open reading frames from the right arm of yeast chromosome XVI. Waśkiewicz-Staniorowska B, et al. Yeast, 1998 Aug. PMID 9730282
    2. The contribution of a zinc finger motif to the function of yeast ribosomal protein YL37a. Rivlin AA, et al. J Mol Biol, 1999 Dec 10. PMID 10588896
    3. The role of the zinc finger motif and of the residues at the amino terminus in the function of yeast ribosomal protein YL37a. Dresios J, et al. J Mol Biol, 2002 Feb 22. PMID 11866512
    4. The dedicated chaperones of eL43, Puf6 and Loc1 can also bind RPL43 mRNA and regulate the production of this ribosomal protein. Yueh LY, et al. J Biochem, 2022 Jan 7. PMID 34661244
    5. Analysis of subunit folding contribution of three yeast large ribosomal subunit proteins required for stabilisation and processing of intermediate nuclear rRNA precursors. Pöll G, et al. PLoS One, 2021. PMID 34813592, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results found that Puf6 and Loc1 are critical to maintaining the stability of Rpl43. Mutation of any one protein results in blockages at similar steps during biogenesis. Puf6 and Loc1 could interact with nascent Rpl43 co-translationally via the N-terminus of Rpl43. Correct formation of the Puf6, Loc1, and Rpl43 ternary complex is required to properly proceed to the next step in 60S biogenesis.
      Title: Puf6 and Loc1 Are the Dedicated Chaperones of Ribosomal Protein Rpl43 in Saccharomyces cerevisiae.
    2. Puf6 and Loc1 facilitate Rpl43 loading and are sequentially released from 60S after incorporation of Rpl43 into ribosomes in yeast.
      Title: The Roles of Puf6 and Loc1 in 60S Biogenesis Are Interdependent, and Both Are Required for Efficient Accommodation of Rpl43.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IC
    Inferred by Curator
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L43A
    NP_015368.1
    • Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      654166..654847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184140.1 → NP_015368.1  TPA: ribosomal 60S subunit protein L43A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015368.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWR3, P0CX25, P0CX26, P49631
      UniProtKB/TrEMBL
      A6ZQ50, B3LLA2, C8ZBP1, G2WH97
      Conserved Domains (1) summary
      PTZ00255
      Location:1 → 88
      PTZ00255; 60S ribosomal protein L37a; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CX25.1
    P0CX26.1

    Gene LinkOut

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    Other Literature Sources
    Molecular Biology Databases
    Research Materials