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    KRE6 beta-glucan synthesis-associated protein KRE6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856287, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KRE6
    Official Full Name
    beta-glucan synthesis-associated protein KRE6
    Primary source
    SGD:S000006363
    Locus tag
    YPR159W
    See related
    AllianceGenome:SGD:S000006363; FungiDB:YPR159W; VEuPathDB:YPR159W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CWH48
    Summary
    Enables glucosidase activity. Involved in (1->6)-beta-D-glucan biosynthetic process and fungal-type cell wall organization. Located in several cellular components, including endoplasmic reticulum membrane; site of polarized growth; and transport vesicle. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KRE6 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (857583..859745)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene gag-pol fusion protein Neighboring gene gag protein Neighboring gene tRNA-Ala Neighboring gene uncharacterized protein Neighboring gene tRNA-Gly Neighboring gene glycogen phosphorylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast beta-glucan synthesis: KRE6 encodes a predicted type II membrane protein required for glucan synthesis in vivo and for glucan synthase activity in vitro. Roemer T, et al. Proc Natl Acad Sci U S A, 1991 Dec 15. PMID 1837148, Free PMC Article
    2. Evidence for Proinflammatory β-1,6 Glucans in the Pneumocystis carinii Cell Wall. Kottom TJ, et al. Infect Immun, 2015 Jul. PMID 25916991, Free PMC Article
    3. Kre6 protein essential for yeast cell wall beta-1,6-glucan synthesis accumulates at sites of polarized growth. Kurita T, et al. J Biol Chem, 2011 Mar 4. PMID 21193403, Free PMC Article
    4. DNA sequence analysis of a 10.4 kbp region on the right arm of yeast chromosome XVI positions GPH1 and SGV1 adjacent to KRE6, and identifies two novel tRNA genes. Roemer T, et al. Yeast, 1994 Nov. PMID 7871892
    5. Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis. Kitamura A, et al. Antimicrob Agents Chemother, 2009 Feb. PMID 19015325, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Saccharomyces cerevisiae CellWall Remodeling in the Absence of Knr4 and Kre6 Revealed by Nano-FourierTransform Infrared Spectroscopy.
      Title: Saccharomyces cerevisiae CellWall Remodeling in the Absence of Knr4 and Kre6 Revealed by Nano-FourierTransform Infrared Spectroscopy.
    2. the action of multiple ER chaperon-like proteins is required for proper folding and localization of Kre6 and probably Skn1 to function in beta-1,6-glucan synthesis.
      Title: Action of multiple endoplasmic reticulum chaperon-like proteins is required for proper folding and polarized localization of Kre6 protein essential in yeast cell wall β-1,6-glucan synthesis.
    3. This is the first evidence of a beta-1,6-glucan-related protein, Kre6, showing the polarized membrane localization that correlates with its biological function
      Title: Kre6 protein essential for yeast cell wall beta-1,6-glucan synthesis accumulates at sites of polarized growth.
    4. Keg1 and Kre6 have a cooperative role in beta-1,6-glucan synthesis in S. cerevisiae.
      Title: KEG1/YFR042w encodes a novel Kre6-binding endoplasmic reticulum membrane protein responsible for beta-1,6-glucan synthesis in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucosidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in (1->6)-beta-D-glucan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in (1->6)-beta-D-glucan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck HDA PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in site of polarized growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-glucan synthesis-associated protein KRE6
    NP_015485.1
    • Glucosyl hydrolase required for beta-1,6-glucan biosynthesis; type II integral membrane protein that localizes to ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; KRE6 has a paralog, SKN1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      857583..859745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184256.1 → NP_015485.1  TPA: beta-glucan synthesis-associated protein KRE6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015485.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4F9, P32486, Q06472
      UniProtKB/TrEMBL
      A6ZX34, B3LKB9, B5VTU3, C8ZJI2, G2WPX1, N1NW62
      Conserved Domains (1) summary
      pfam03935
      Location:209 → 711
      SKN1; Beta-glucan synthesis-associated protein (SKN1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32486.2

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