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    SPO7 Nem1-Spo7 phosphatase regulatory subunit SPO7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851224, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SPO7
    Official Full Name
    Nem1-Spo7 phosphatase regulatory subunit SPO7
    Primary source
    SGD:S000000007
    Locus tag
    YAL009W
    See related
    AllianceGenome:SGD:S000000007; FungiDB:YAL009W; VEuPathDB:YAL009W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to phosphoprotein phosphatase activity. Involved in negative regulation of phospholipid biosynthetic process; nuclear envelope organization; and reticulophagy. Located in membrane. Part of Nem1-Spo7 phosphatase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SPO7 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (135854..136633)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene Swc3p Neighboring gene Mdm10p Neighboring gene Fun14p Neighboring gene Erp2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation, characterization and regulation of the SPO7 sporulation gene. Whyte W, et al. Gene, 1990 Oct 30. PMID 2253888
    2. Yeast nuclear envelope subdomains with distinct abilities to resist membrane expansion. Campbell JL, et al. Mol Biol Cell, 2006 Apr. PMID 16467382, Free PMC Article
    3. Sequencing of chromosome I from Saccharomyces cerevisiae: analysis of a 32 kb region between the LTE1 and SPO7 genes. Ouellette BF, et al. Genome, 1993 Feb. PMID 8458570
    4. Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region. Clark MW, et al. Yeast, 1994 Apr. PMID 7941740
    5. Genes controlling meiosis and spore formation in yeast. Esposito MS, et al. Genetics, 1974 Sep. PMID 4613605, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation-mediated regulation of the Nem1-Spo7/Pah1 phosphatase cascade in yeast lipid synthesis.
      Title: Phosphorylation-mediated regulation of the Nem1-Spo7/Pah1 phosphatase cascade in yeast lipid synthesis.
    2. The Spo7 sequence LLI is required for Nem1-Spo7/Pah1 phosphatase cascade function in yeast lipid metabolism.
      Title: The Spo7 sequence LLI is required for Nem1-Spo7/Pah1 phosphatase cascade function in yeast lipid metabolism.
    3. the TORC1-Nem1/Spo7-Pah1 axis is a master regulator of not only macroautophagy but also microautophagy in budding yeast
      Title: The TORC1-Nem1/Spo7-Pah1/lipin axis regulates microautophagy induction in budding yeast.
    4. Together, our data suggest that Nem1-Sop7-mediated regulation of membrane biogenesis is needed to promote mitophagy in yeast.
      Title: The Nem1-Spo7 protein phosphatase complex is required for efficient mitophagy in yeast.
    5. Acidic tail-dependent binding and dephosphorylation of Pah1p by the Nem1p-Spo7p complex is an important determinant of its function in lipid and membrane biogenesis.
      Title: Regulation of lipid droplet and membrane biogenesis by the acidic tail of the phosphatidate phosphatase Pah1p.
    6. Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway.
      Title: Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of phospholipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nuclear envelope organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear envelope organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of phospholipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reticulophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Nem1-Spo7 phosphatase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Nem1-Spo7 phosphatase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nem1-Spo7 phosphatase regulatory subunit SPO7
    NP_009393.1
    • Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear/ER membrane association and activation of Pah1p, a phosphatidate phosphatase involved in the production of diacylglycerol DAG for lipid droplet biogenesis; phosphatase activity of the Nem1p-Spo7p complex is inhibited by Ice2p; regulates nuclear growth by controlling phospholipid biosynthesis; required for normal nuclear envelope morphology, premeiotic replication, and sporulation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      135854..136633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178154.1 → NP_009393.1  TPA: Nem1-Spo7 phosphatase regulatory subunit SPO7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009393.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPK9, P18410
      UniProtKB/TrEMBL
      C7GPM5, G2W8M3, N1P934
      Conserved Domains (1) summary
      pfam03907
      Location:45 → 248
      Spo7; Spo7-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18410.1

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