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    AHK1 Ahk1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851486, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AHK1
    Official Full Name
    Ahk1p
    Primary source
    SGD:S000002231
    Locus tag
    YDL073W
    See related
    AllianceGenome:SGD:S000002231; FungiDB:YDL073W; VEuPathDB:YDL073W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables MAP-kinase scaffold activity. Involved in negative regulation of protein phosphorylation and osmosensory signaling pathway via Sho1 osmosensor. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AHK1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (326613..329567)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene E3 ubiquitin-protein ligase BRE1 Neighboring gene Yet3p Neighboring gene Bdf2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Scaffold Protein Ahk1, Which Associates with Hkr1, Sho1, Ste11, and Pbs2, Inhibits Cross Talk Signaling from the Hkr1 Osmosensor to the Kss1 Mitogen-Activated Protein Kinase. Nishimura A, et al. Mol Cell Biol, 2016 Jan 19. PMID 26787842, Free PMC Article
    2. Cnm1 mediates nucleus-mitochondria contact site formation in response to phospholipid levels. Eisenberg-Bord M, et al. J Cell Biol, 2021 Nov 1. PMID 34694322, Free PMC Article
    3. Regulation of cell polarity through phosphorylation of Bni4 by Pho85 G1 cyclin-dependent kinases in Saccharomyces cerevisiae. Zou J, et al. Mol Biol Cell, 2009 Jul. PMID 19458192, Free PMC Article
    4. The unfolded protein response is necessary but not sufficient to compensate for defects in disulfide isomerization. Kim JH, et al. J Biol Chem, 2009 Apr 17. PMID 19233841, Free PMC Article
    5. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ahk1 is a scaffold protein in the HKR1 subbranch and prevents incorrect signal flow from Hkr1 to Kss1
      Title: Scaffold Protein Ahk1, Which Associates with Hkr1, Sho1, Ste11, and Pbs2, Inhibits Cross Talk Signaling from the Hkr1 Osmosensor to the Kss1 Mitogen-Activated Protein Kinase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables MAP-kinase scaffold activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in osmosensory signaling pathway via Sho1 osmosensor IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in osmosensory signaling pathway via Sho1 osmosensor IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Ahk1p
    NP_010210.1
    • Scaffold protein in the HKR1 sub-branch of the Hog1p-signaling pathway; physically interacts with the cytoplasmic domain of Hkr1p, and with Sho1p, Pbs2p, and Ste11p; prevents cross-talk signaling from Hkr1p of the osmotic stress MAPK cascade to the Kss1p MAPK cascade; non-essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      326613..329567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180132.1 → NP_010210.1  TPA: Ahk1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010210.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRS6, Q07454
      UniProtKB/TrEMBL
      A6ZXQ5, N1P7Q7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07454.1

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