LYS21 homocitrate synthase LYS21 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: LYS21
Official Full Name: homocitrate synthase LYS21
Primary source: SGD:S000002289
Locus tag: YDL131W
See related: AllianceGenome:SGD:S000002289; FungiDB:YDL131W; VEuPathDB:YDL131W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables homocitrate synthase activity. Involved in lysine biosynthetic process via aminoadipic acid. Located in nucleus. Human ortholog(s) of this gene implicated in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency and amino acid metabolic disorder. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase) and HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See LYS21 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (227393..228715)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results show that during growth on ethanol, homocitrate is mainly synthesized through Lys21p, while under fermentative metabolism, Lys20p and Lys21p play redundant roles
Title: Specialization of the paralogue LYS21 determines lysine biosynthesis under respiratory metabolism in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables homocitrate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables homocitrate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables homocitrate synthase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in lysine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lysine biosynthetic process via aminoadipic acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in lysine biosynthetic process via aminoadipic acid	IEA Inferred from Electronic Annotation more info
involved_in lysine biosynthetic process via aminoadipic acid	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lysine biosynthetic process via aminoadipic acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small molecule biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: homocitrate synthase LYS21

NP_010151.1

EC 2.3.3.14

Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

227393..228715

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180190.1 → NP_010151.1 TPA: homocitrate synthase LYS21 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010151.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRL8, E9P8Z7, Q12122

UniProtKB/TrEMBL

A6ZXJ7, B3LH22, C8Z6H2, G2WC30, N1P3Z8

Conserved Domains (1) summary

cd07948
Location:37 → 298

DRE_TIM_HCS; Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain