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    DAD1 Dad1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851579, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DAD1
    Official Full Name
    Dad1p
    Primary source
    SGD:S000002423
    Locus tag
    YDR016C
    See related
    AllianceGenome:SGD:S000002423; FungiDB:YDR016C; VEuPathDB:YDR016C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to microtubule plus-end binding activity. Involved in attachment of spindle microtubules to kinetochore; positive regulation of attachment of spindle microtubules to kinetochore; and positive regulation of microtubule polymerization. Part of DASH complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DAD1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (478474..478758, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Rad61p Neighboring gene Hed1p Neighboring gene inositol polyphosphate kinase KCS1 Neighboring gene putative acyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Dad1 subunit of the yeast kinetochore Dam1 complex is an intrinsically disordered protein. Waldo JT, et al. Biochem Biophys Res Commun, 2010 Sep 24. PMID 20727855
    2. Production and initial characterization of Dad1p, a component of the Dam1-DASH kinetochore complex. Waldo J, et al. PLoS One, 2008. PMID 19065263, Free PMC Article
    3. Exhaustive identification of interaction domains using a high-throughput method based on two-hybrid screening and PCR-convergence: molecular dissection of a kinetochore subunit Spc34p. Ikeuchi A, et al. Nucleic Acids Res, 2003 Dec 1. PMID 14627828, Free PMC Article
    4. A Kinesin-5, Cin8, Recruits Protein Phosphatase 1 to Kinetochores and Regulates Chromosome Segregation. Suzuki A, et al. Curr Biol, 2018 Sep 10. PMID 30174190, Free PMC Article
    5. A conserved site on Ndc80 complex facilitates dynamic recruitment of Mps1 to yeast kinetochores to promote accurate chromosome segregation. Parnell EJ, et al. Curr Biol, 2024 Jun 3. PMID 38776906,

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the work presented here shows that are differences between Dad1 from C. albicans and S. cerevisiae.
      Title: The Dad1 subunit of the yeast kinetochore Dam1 complex is an intrinsically disordered protein.
    2. The expression, solubilization, purification and refolding of Dad1p, one of the Dam1-DASH complex subunits, is reported.
      Title: Production and initial characterization of Dad1p, a component of the Dam1-DASH kinetochore complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DASH complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DASH complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of DASH complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitotic spindle pole body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Dad1p
    NP_010299.3
    • Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      478474..478758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180324.3 → NP_010299.3  TPA: Dad1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010299.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS02, Q12248
      UniProtKB/TrEMBL
      A6ZXY0, B3LGP7, C7GLY0, C8Z4T6, G2WAC3, N1PAB6
      Conserved Domains (1) summary
      pfam08649
      Location:19 → 73
      DASH_Dad1; DASH complex subunit Dad1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12248.1

    Gene LinkOut

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