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    EBS1 Ebs1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851787, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EBS1
    Official Full Name
    Ebs1p
    Primary source
    SGD:S000002614
    Locus tag
    YDR206W
    See related
    AllianceGenome:SGD:S000002614; FungiDB:YDR206W; VEuPathDB:YDR206W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable telomerase RNA binding activity and telomeric DNA binding activity. Involved in DNA recombination; negative regulation of translation; and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in P-body. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EBS1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (862054..864708)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ubiquinone biosynthesis protein COQ4 Neighboring gene metal cation transporter MSC2 Neighboring gene DNA-binding transcriptional regulator UME6 Neighboring gene 1-phosphatidylinositol-4-phosphate 5-kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of Mg(II) in DNA cleavage site recognition in group II intron ribozymes: solution structure and metal ion binding sites of the RNA-DNA complex. Skilandat M, et al. J Biol Chem, 2014 Jul 25. PMID 24895129, Free PMC Article
    2. Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay. Luke B, et al. Nucleic Acids Res, 2007. PMID 17984081, Free PMC Article
    3. The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA. Zhou J, et al. Mol Cell Biol, 2000 Mar. PMID 10688642, Free PMC Article
    4. Ebs1p, a negative regulator of gene expression controlled by the Upf proteins in the yeast Saccharomyces cerevisiae. Ford AS, et al. Eukaryot Cell, 2006 Feb. PMID 16467471, Free PMC Article
    5. A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. Downey M, et al. Cell, 2006 Mar 24. PMID 16564010

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ebs1p is involved in nonsense-mediated RNA decay and behaves similarly to human Smg proteins.
      Title: Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay.
    2. Ebs1p inhibits translation, most likely through effects on eIF-4E rather than on decapping.
      Title: Ebs1p, a negative regulator of gene expression controlled by the Upf proteins in the yeast Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables telomerase RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of telomerase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ebs1p
    NP_010492.3
    • Protein involved in translation inhibition and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors; EBS1 has a paralog, EST1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      862054..864708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180514.3 → NP_010492.3  TPA: Ebs1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010492.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSI7, Q03466
      UniProtKB/TrEMBL
      C7GMZ3, N1P8E2
      Conserved Domains (2) summary
      pfam10373
      Location:228 → 516
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:80 → 214
      EST1; Telomerase activating protein Est1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03466.1

    Gene LinkOut

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