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    RNH202 Rnh202p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851873, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RNH202
    Official Full Name
    Rnh202p
    Primary source
    SGD:S000002687
    Locus tag
    YDR279W
    See related
    AllianceGenome:SGD:S000002687; FungiDB:YDR279W; VEuPathDB:YDR279W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to RNA-DNA hybrid ribonuclease activity. Involved in RNA catabolic process. Located in nucleus. Part of ribonuclease H2 complex. Used to study Aicardi-Goutieres syndrome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RNH202 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1019368..1020420)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Mth1p Neighboring gene tRNA-Glu Neighboring gene exosome non-catalytic core subunit RRP45 Neighboring gene Phm6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome instability consequences of RNase H2 Aicardi-Goutières syndrome alleles. Potenski CJ, et al. DNA Repair (Amst), 2019 Dec. PMID 30975634, Free PMC Article
    2. RNase H2 of Saccharomyces cerevisiae is a complex of three proteins. Jeong HS, et al. Nucleic Acids Res, 2004. PMID 14734815, Free PMC Article
    3. RNase H1 and H2 Are Differentially Regulated to Process RNA-DNA Hybrids. Lockhart A, et al. Cell Rep, 2019 Nov 26. PMID 31775053
    4. RNase H2 roles in genome integrity revealed by unlinking its activities. Chon H, et al. Nucleic Acids Res, 2013 Mar 1. PMID 23355612, Free PMC Article
    5. Effect of the disease-causing mutations identified in human ribonuclease (RNase) H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII. Rohman MS, et al. FEBS J, 2008 Oct. PMID 18721139, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to RNA-DNA hybrid ribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA-DNA hybrid ribonuclease activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonuclease H2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonuclease H2 complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rnh202p
    NP_010565.3
    • Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS2 that causes Aicardi-Goutieres syndrome

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1019368..1020420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180587.3 → NP_010565.3  TPA: Rnh202p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010565.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSQ9, Q05635, Q6Q5R1
      UniProtKB/TrEMBL
      A6ZYM8, B3LG15, B5VGF8, C8Z5J2, N1P6S2
      Conserved Domains (1) summary
      cd09270
      Location:12 → 348
      RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05635.1

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