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    SLF1 Slf1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852127, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SLF1
    Official Full Name
    Slf1p
    Primary source
    SGD:S000002923
    Locus tag
    YDR515W
    See related
    AllianceGenome:SGD:S000002923; FungiDB:YDR515W; VEuPathDB:YDR515W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SRO99
    Summary
    Enables RNA binding activity. Involved in intracellular copper ion homeostasis and regulation of translation. Located in cytoplasmic stress granule. Orthologous to human LARP1 (La ribonucleoprotein 1, translational regulator) and LARP1B (La ribonucleoprotein 1B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SLF1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1473429..1474772)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Emi1p Neighboring gene dithiol glutaredoxin GRX2 Neighboring gene uncharacterized protein Neighboring gene putative glucokinase Neighboring gene Grh1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of SLF1 as a new copper homeostasis gene involved in copper sulfide mineralization in Saccharomyces cerevisiae. Yu W, et al. Mol Cell Biol, 1996 May. PMID 8628314, Free PMC Article
    2. Repression of mitochondrial translation, respiration and a metabolic cycle-regulated gene, SLF1, by the yeast Pumilio-family protein Puf3p. Chatenay-Lapointe M, et al. PLoS One, 2011. PMID 21655263, Free PMC Article
    3. Two yeast La motif-containing proteins are RNA-binding proteins that associate with polyribosomes. Sobel SG, et al. Mol Biol Cell, 1999 Nov. PMID 10564276, Free PMC Article
    4. Interaction of the La-related protein Slf1 with colliding ribosomes maintains translation of oxidative-stress responsive mRNAs. Jennings MD, et al. Nucleic Acids Res, 2023 Jun 23. PMID 37070186, Free PMC Article
    5. Paralogous translation factors target distinct mRNAs to differentially regulate tolerance to oxidative stress in yeast. Cunningham J, et al. Nucleic Acids Res, 2023 Sep 8. PMID 37449412, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction of the La-related protein Slf1 with colliding ribosomes maintains translation of oxidative-stress responsive mRNAs.
      Title: Interaction of the La-related protein Slf1 with colliding ribosomes maintains translation of oxidative-stress responsive mRNAs.
    2. our results indicate that Slf1p mediates a translational response to oxidative stress via mRNA-specific translational control.
      Title: The yeast La related protein Slf1p is a key activator of translation during the oxidative stress response.
    3. Data identified the cytoplasmic translation factor Slf1p as yeast metabolic cycle-regulated gene that is repressed by Puf3p at the post-transcriptional level and promotes respiration and extension of yeast chronological life span when over-expressed.
      Title: Repression of mitochondrial translation, respiration and a metabolic cycle-regulated gene, SLF1, by the yeast Pumilio-family protein Puf3p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in intracellular copper ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasmic stress granule HDA PubMed 
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Slf1p
    NP_010803.3
    • RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; role in preventing L-A mycovirus pathogenesis; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1473429..1474772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180823.3 → NP_010803.3  TPA: Slf1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010803.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTD6, E9P8Z6, Q12034
      UniProtKB/TrEMBL
      G2WBP2, N1P5V3
      Conserved Domains (1) summary
      COG5193
      Location:3 → 443
      LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12034.1

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