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    PUP3 proteasome core particle subunit beta 3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856830, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PUP3
    Official Full Name
    proteasome core particle subunit beta 3
    Primary source
    SGD:S000000896
    Locus tag
    YER094C
    See related
    AllianceGenome:SGD:S000000896; FungiDB:YER094C; VEuPathDB:YER094C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SCS32
    Summary
    Enables endopeptidase activator activity. Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in nucleus. Part of proteasome core complex, beta-subunit complex. Used to study cancer. Orthologous to human PSMB3 (proteasome 20S subunit beta 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PUP3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (348729..349346, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene TORC2 complex subunit TSC11 Neighboring gene Aim11p Neighboring gene recombinase RAD51 Neighboring gene Shc1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic evidence for selective degradation of RNA polymerase subunits by the 20S proteasome in Saccharomyces cerevisiae. Nouraini S, et al. Nucleic Acids Res, 1997 Sep 15. PMID 9278475, Free PMC Article
    2. Identification of the yeast 20S proteasome catalytic centers and subunit interactions required for active-site formation. Arendt CS, et al. Proc Natl Acad Sci U S A, 1997 Jul 8. PMID 9207060, Free PMC Article
    3. Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1. Nussbaum AK, et al. Proc Natl Acad Sci U S A, 1998 Oct 13. PMID 9770515, Free PMC Article
    4. Proteasome beta-type subunits: unequal roles of propeptides in core particle maturation and a hierarchy of active site function. Jäger S, et al. J Mol Biol, 1999 Aug 27. PMID 10452902
    5. The catalytic sites of 20S proteasomes and their role in subunit maturation: a mutational and crystallographic study. Groll M, et al. Proc Natl Acad Sci U S A, 1999 Sep 28. PMID 10500111, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables endopeptidase activator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasomal ubiquitin-independent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasomal ubiquitin-independent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex, beta-subunit complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    proteasome core particle subunit beta 3
    NP_011020.3
    • Beta 3 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit C10

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      348729..349346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178985.3 → NP_011020.3  TPA: proteasome core particle subunit beta 3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011020.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM02, P25451
      UniProtKB/TrEMBL
      A6ZR51, B3LRL3, C7GRS8, C8Z7B3, G2WCY6, N1PA50
      Conserved Domains (1) summary
      cd03759
      Location:8 → 201
      proteasome_beta_type_3; proteasome beta type-3 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25451.1

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