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    TPN1 Tpn1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852689, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TPN1
    Official Full Name
    Tpn1p
    Primary source
    SGD:S000003154
    Locus tag
    YGL186C
    See related
    AllianceGenome:SGD:S000003154; FungiDB:YGL186C; VEuPathDB:YGL186C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables vitamin transmembrane transporter activity. Involved in vitamin transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TPN1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (151037..152776, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene cytochrome c oxidase subunit IV Neighboring gene putative hydroxyacid dehydrogenase Neighboring gene cystathionine beta-lyase STR3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae. Stolz J, et al. J Biol Chem, 2003 May 23. PMID 12649274
    2. Amiloride uptake and toxicity in fission yeast are caused by the pyridoxine transporter encoded by bsu1+ (car1+). Stolz J, et al. Eukaryot Cell, 2005 Feb. PMID 15701794, Free PMC Article
    3. Plasticity of an ultrafast interaction between nucleoporins and nuclear transport receptors. Milles S, et al. Cell, 2015 Oct 22. PMID 26456112, Free PMC Article
    4. Various cytosine/adenine permease homologues are involved in the toxicity of 5-fluorocytosine in Saccharomyces cerevisiae. Paluszynski JP, et al. Yeast, 2006 Jul 15. PMID 16845689
    5. A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions. Kanellis P, et al. PLoS Genet, 2007 Aug. PMID 17696614, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables vitamin transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vitamin transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vitamin transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vitamin transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tpn1p
    NP_011329.1
    • Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      151037..152776 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181051.1 → NP_011329.1  TPA: Tpn1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011329.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTW8, P53099, Q874L4
      UniProtKB/TrEMBL
      A6ZU02, B5VIE5, C7GX08, N1P4A2
      Conserved Domains (1) summary
      TIGR00800
      Location:70 → 510
      ncs1; NCS1 nucleoside transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53099.1

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