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    PUP2 proteasome core particle subunit alpha 5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853168, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PUP2
    Official Full Name
    proteasome core particle subunit alpha 5
    Primary source
    SGD:S000003485
    Locus tag
    YGR253C
    See related
    AllianceGenome:SGD:S000003485; FungiDB:YGR253C; VEuPathDB:YGR253C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DOA5
    Summary
    Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in proteasome storage granule. Part of proteasome core complex, alpha-subunit complex. Orthologous to human PSMA5 (proteasome 20S subunit alpha 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PUP2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (998358..999140, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Nop19p Neighboring gene histone acetyltransferase GCN5 Neighboring gene phosphopyruvate hydratase ENO1 Neighboring gene putative N,N-dimethylaniline monooxygenase COQ6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of an essential yeast gene encoding a proteasomal subunit. Georgatsou E, et al. FEBS Lett, 1992 Mar 24. PMID 1544471
    2. A novel proteasome assembly intermediate bypasses the need to form α-rings first. Hammack LJ, et al. Biochem Biophys Res Commun, 2020 Feb 17. PMID 32081431
    3. Biogenesis, structure and function of the yeast 20S proteasome. Chen P, et al. EMBO J, 1995 Jun 1. PMID 7781614, Free PMC Article
    4. Mutations of Cys and Ser residues in the α5-subunit of the 20S proteasome from Saccharomyces cerevisiae affects gating and chronological lifespan. Leme JMM, et al. Arch Biochem Biophys, 2019 May 15. PMID 30940569
    5. Plasticity in eucaryotic 20S proteasome ring assembly revealed by a subunit deletion in yeast. Velichutina I, et al. EMBO J, 2004 Feb 11. PMID 14739934, Free PMC Article

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasomal ubiquitin-independent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasomal ubiquitin-independent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex, alpha-subunit complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in proteasome storage granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proteasome core particle subunit alpha 5
    NP_011769.1
    • Alpha 5 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit zeta

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      998358..999140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181382.1 → NP_011769.1  TPA: proteasome core particle subunit alpha 5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011769.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV33, P32379
      UniProtKB/TrEMBL
      A6ZUR1, B3LHY7, C7GNH7, C8Z9E5, G2WEX9, N1P678
      Conserved Domains (1) summary
      cd03753
      Location:8 → 222
      proteasome_alpha_type_5; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32379.2

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