KOG1 ubiquitin-binding TORC1 subunit KOG1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: KOG1
Official Full Name: ubiquitin-binding TORC1 subunit KOG1
Primary source: SGD:S000001229
Locus tag: YHR186C
See related: AllianceGenome:SGD:S000001229; FungiDB:YHR186C; VEuPathDB:YHR186C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LAS24
Summary: Enables ubiquitin binding activity. Involved in cellular response to starvation and regulation of cell growth. Located in fungal-type vacuole membrane and plasma membrane. Part of TORC1 complex. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human RPTOR (regulatory associated protein of MTOR complex 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See KOG1 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (475999..480672, complement)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TORC1 and PKA activity towards ribosome biogenesis oscillates in synchrony with the budding yeast cell cycle.
Title: TORC1 and PKA activity towards ribosome biogenesis oscillates in synchrony with the budding yeast cell cycle.
Results show that H(+) influx coupled to nutrient uptake stimulates Target of Rapamycin Complex 1 (TORC1) activity and that plasma membrane H(+)-ATPase (Pma1) is a key actor in this mechanism.
Title: The yeast H(+)-ATPase Pma1 promotes Rag/Gtr-dependent TORC1 activation in response to H(+)-coupled nutrient uptake.
TORC1/Kog1 signaling controls Stu2 localization and thereby contributes to proper microtubule cytoskeletal organization in interphase and mitosis.
Title: TORC1 signaling exerts spatial control over microtubule dynamics by promoting nuclear export of Stu2.
findings demonstrate that TORC1 is an effector of Gcn2 in amino acid signaling, hence defining a novel mechanism by which TORC1 senses amino acid starvation
Title: General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae.
interactions between the FRB (rapamycin binding) domain and kinase domains, as well as between the FRB domain and the TORC1 component Kog1p, regulate TOR activity as well as contribute to the mechanism of caffeine resistance
Title: Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in TOR signaling	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell growth	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of TORC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC1 complex	IEA Inferred from Electronic Annotation more info
part_of TORC1 complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	HDA more info	PubMed
located_in fungal-type vacuole membrane	HDA more info	PubMed
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin-binding TORC1 subunit KOG1

NP_012056.1

Ubiquitin-binding protein; centrally regulates metabolic homeostasis and carbon utilization during nutrient limitation by managing Snf1p activity; subunit of TORC1 rapamycin-sensitive complex involved in growth control; central scaffold that holds the different components of TORC1 together; contains four HEAT repeats and seven WD-40 repeats

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

475999..480672 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179317.1 → NP_012056.1 TPA: ubiquitin-binding TORC1 subunit KOG1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012056.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLD4, P38873

UniProtKB/TrEMBL

A6ZT92, C7GRK8, N1P4W1

Conserved Domains (5) summary

sd00044
Location:738 → 769

HEAT; HEAT repeat [structural motif]

sd00039
Location:1258 → 1296

7WD40; WD40 repeat [structural motif]

pfam02985
Location:783 → 812

HEAT; HEAT repeat

pfam14538
Location:81 → 232

Raptor_N; Raptor N-terminal CASPase like domain

cl29593
Location:1224 → 1548

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...