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    PGU1 endo-polygalacturonase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853618, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PGU1
    Official Full Name
    endo-polygalacturonase
    Primary source
    SGD:S000003914
    Locus tag
    YJR153W
    See related
    AllianceGenome:SGD:S000003914; FungiDB:YJR153W; VEuPathDB:YJR153W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PGL1; PSM1
    Summary
    Enables polygalacturonase activity. Involved in pectin catabolic process. Located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PGU1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (722815..723900)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene allantoate permease Neighboring gene uncharacterized protein Neighboring gene putative aryl-alcohol dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endo-polygalacturonase in Saccharomyces wine yeasts: effect of carbon source on enzyme production. Radoi F, et al. FEMS Yeast Res, 2005 Apr. PMID 15780666
    2. Production and partial characterization of an endopolygalacturonase from Saccharomyces cerevisiae. Blanco P, et al. Can J Microbiol, 1994 Nov. PMID 7804908
    3. Cloning, molecular characterization, and expression of an endo-polygalacturonase-encoding gene from Saccharomyces cerevisiae IM1-8b. Blanco P, et al. FEMS Microbiol Lett, 1998 Jul 15. PMID 9682473
    4. Cloning, sequence analysis and overexpression of a Saccharomyces cerevisiae endopolygalacturonase-encoding gene (PGL1). Gognies S, et al. Yeast, 1999 Jan 15. PMID 10028181
    5. Cloning, targeted disruption and heterologous expression of the Kluyveromyces marxianus endopolygalacturonase gene (EPG1). Siekstele R, et al. Yeast, 1999 Mar 15. PMID 10206190

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpressing the PGU1 gene of S. paradoxus or S. cerevisiae did not make much difference, showing that the higher activity of S. paradoxus strains could be due to a different regulation mechanism rather than to a different sequence of PGU1.
      Title: Comparative characterization of endo-polygalacturonase (Pgu1) from Saccharomyces cerevisiae and Saccharomyces paradoxus under winemaking conditions.
    2. The results of this study suggest that PGU1 is silenced by being folded into a heterochromatin-like structure at its subtelomeric position on chromosome X.
      Title: Epigenetic regulation of PGU1 transcription in Saccharomyces cerevisiae.
    3. Expression of PGU1 was found to be determined by the transcription level of its two transcription factors TEC1 and STE12.
      Title: Regulation of endo-polygalacturonase activity in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polygalacturonase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polygalacturonase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polygalacturonase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pectin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pectin catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pectin catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    endo-polygalacturonase
    NP_012687.3
    • Endo-polygalacturonase; pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      722815..723900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181811.3 → NP_012687.3  TPA: endo-polygalacturonase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012687.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWX2, E9P8V0, P47180
      UniProtKB/TrEMBL
      A0A024BTY8, A6ZQB1, B3LQN3, C8ZBV3, N1P1C5
      Conserved Domains (1) summary
      pfam00295
      Location:43 → 361
      Glyco_hydro_28; Glycosyl hydrolases family 28
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47180.1

    Gene LinkOut

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