MMS1 Mms1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MMS1
Official Full Name: Mms1p
Primary source: SGD:S000006368
Locus tag: YPR164W
See related: AllianceGenome:SGD:S000006368; FungiDB:YPR164W; VEuPathDB:YPR164W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RTT108; SLM6
Summary: Involved in DNA metabolic process; nonfunctional rRNA decay; and transposable element silencing. Part of Cul8-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MMS1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (870703..874926)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mms1, an ubiquitin ligase complex protein, was identified as a novel G4-DNA-binding protein that supports genome stability by aiding Pif1 helicase binding to these regions. In this perspective review, we discuss the question if G4-DNA interacting proteins are fundamental for helicase function and specificity at G4-DNA structures
Title: Mms1 is an assistant for regulating G-quadruplex DNA structures.
propose a mechanistic model in which Mms1 binds to specific G-rich/G4 motif located on the lagging strand template for DNA replication and supports Pif1 function, DNA replication and genome integrity
Title: Mms1 binds to G-rich regions in Saccharomyces cerevisiae and influences replication and genome stability.
Cul8-Mms1, as part of various protein complexes, is involved in the regulation of chromatin metabolism
Title: Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencing.
Data suggest that in the absence of telomerase, a very short telomere is first maintained in a pre-signalling state by a RAD52-MMS1-dependent pathway and then switches to a signalling state leading to senescence through a Mec1p-dependent checkpoint.
Title: A two-step model for senescence triggered by a single critically short telomere.
Rtt101(Mms1) ubiquitin ligase complex might be required to reorganize replication forks that encounter DNA lesions.
Title: Rtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNA.
cells lacking MMS1 have severly defective recombination between sister chromatids or between homologous chromosomes induced by agents that block replisomes and are defective in recovery from Methylmethane Sulfonate-induced replisome stalling
Title: Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage.
Data from this study show that defects in the Rad51-Sgs1-dependent and Sgs1-dependent lesion-bypass pathways activate Rad59-Rad1- and Rad59-dependent pathways, respectively, resulting in uSCR.
Title: Activation of a novel pathway involving Mms1 and Rad59 in sgs1 cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in nonfunctional rRNA decay	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in recombinational repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in replication fork processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transposable element silencing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul8-RING ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mms1p

NP_015490.1

Subunit of E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay