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    TCM62 Tcm62p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852332, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TCM62
    Official Full Name
    Tcm62p
    Primary source
    SGD:S000000248
    Locus tag
    YBR044C
    See related
    AllianceGenome:SGD:S000000248; FungiDB:YBR044C; VEuPathDB:YBR044C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein-folding chaperone binding activity and unfolded protein binding activity. Involved in mitochondrial respiratory chain complex II assembly. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TCM62 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (324341..326059, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene putative acyltransferase Neighboring gene Qdr3p Neighboring gene tRNA-Val Neighboring gene protein phosphatase regulator GIP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism. Vander Heiden MG, et al. J Biol Chem, 2002 Nov 22. PMID 12244097
    2. The Saccharomyces cerevisiae TCM62 gene encodes a chaperone necessary for the assembly of the mitochondrial succinate dehydrogenase (complex II). Dibrov E, et al. J Biol Chem, 1998 Nov 27. PMID 9822678
    3. Pseudomonas-Saccharomyces interactions: influence of fungal metabolism on bacterial physiology and survival. Romano JD, et al. J Bacteriol, 2005 Feb. PMID 15659672, Free PMC Article
    4. The translational activator Sov1 coordinates mitochondrial gene expression with mitoribosome biogenesis. Seshadri SR, et al. Nucleic Acids Res, 2020 Jul 9. PMID 32449921, Free PMC Article
    5. Identification of respiratory chain gene mutations that shorten replicative life span in yeast. Hacioglu E, et al. Exp Gerontol, 2012 Feb. PMID 22137892

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex II assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein refolding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tcm62p
    NP_009600.2
    • Protein involved in assembly of the succinate dehydrogenase complex; mitochondrial; putative chaperone

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      324341..326059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178392.2 → NP_009600.2  TPA: Tcm62p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009600.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZKY8, D6VQ44, P38228, Q9Y793
      UniProtKB/TrEMBL
      G2W950, N1P898
      Conserved Domains (1) summary
      PTZ00114
      Location:124 → 492
      PTZ00114; Heat shock protein 60; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38228.2

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