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    RET3 coatomer subunit zeta [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856097, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RET3
    Official Full Name
    coatomer subunit zeta
    Primary source
    SGD:S000005931
    Locus tag
    YPL010W
    See related
    AllianceGenome:SGD:S000005931; FungiDB:YPL010W; VEuPathDB:YPL010W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Part of COPI vesicle coat. Orthologous to several human genes including COPZ2 (COPI coat complex subunit zeta 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RET3 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (535018..535587)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene mRNA-binding protein RRP12 Neighboring gene Taf3p Neighboring gene Rqc2p Neighboring gene DNA helicase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and functional characterization of yeast zeta-COP. Yamazaki S, et al. J Biochem, 1997 Jan. PMID 9058184
    2. Delta- and zeta-COP, two coatomer subunits homologous to clathrin-associated proteins, are involved in ER retrieval. Cosson P, et al. EMBO J, 1996 Apr 15. PMID 8617224, Free PMC Article
    3. Full-length structural model of RET3 and SEC21 in COPI: identification of binding sites on the appendage for accessory protein recruitment motifs. Alisaraie L, et al. J Mol Model, 2012 Jul. PMID 22246286, Free PMC Article
    4. Molecular structure and flexibility of the yeast coatomer as revealed by electron microscopy. Yip CK, et al. J Mol Biol, 2011 May 20. PMID 21435344, Free PMC Article
    5. Alpha-COP can discriminate between distinct, functional di-lysine signals in vitro and regulates access into retrograde transport. Schröder-Köhne S, et al. J Cell Sci, 1998 Dec. PMID 9811561

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COPI vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of COPI vesicle coat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in COPI-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coatomer subunit zeta
    NP_015315.1
    • Zeta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      535018..535587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183824.1 → NP_015315.1  TPA: coatomer subunit zeta [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015315.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W402, P53600
      UniProtKB/TrEMBL
      A6ZWN6, B3LL52, B5VTF2, C7GU40, C8ZJ17, G2WPH0, N1NVI8
      Conserved Domains (1) summary
      COG5541
      Location:3 → 189
      RET3; Vesicle coat complex COPI, zeta subunit [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53600.1

    Gene LinkOut

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