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    IRC10 Irc10p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854145, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IRC10
    Official Full Name
    Irc10p
    Primary source
    SGD:S000005375
    Locus tag
    YOL015W
    See related
    AllianceGenome:SGD:S000005375; FungiDB:YOL015W; VEuPathDB:YOL015W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Located in prospore membrane leading edge. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IRC10 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (297078..298838)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Esc8p Neighboring gene calmodulin-dependent protein kinase CMK2 Neighboring gene uncharacterized protein Neighboring gene tRNA-Pro

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Meiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast. King GA, et al. Elife, 2019 Aug 9. PMID 31397671, Free PMC Article
    2. The Smk1 MAPK and Its Activator, Ssp2, Are Required for Late Prospore Membrane Development in Sporulating Saccharomyces cerevisiae. Durant M, et al. J Fungi (Basel), 2021 Jan 14. PMID 33466572, Free PMC Article
    3. Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism. Yu R, et al. Nat Commun, 2021 Mar 31. PMID 33790287, Free PMC Article
    4. Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. Alvaro D, et al. PLoS Genet, 2007 Dec. PMID 18085829, Free PMC Article
    5. A visual screen of protein localization during sporulation identifies new components of prospore membrane-associated complexes in budding yeast. Lam C, et al. Eukaryot Cell, 2014 Mar. PMID 24390141, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of IRC10 caused no obvious phenotype, but an ady3 irc10 mutant was completely defective in sporulation and displayed prospore membrane morphologies similar to those of an ssp1 strain.
      Title: A visual screen of protein localization during sporulation identifies new components of prospore membrane-associated complexes in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in prospore membrane leading edge HDA PubMed 

    General protein information

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    Preferred Names
    Irc10p
    NP_014627.1
    • hypothetical protein; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; null mutant displays increased levels of spontaneous Rad52p foci

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      297078..298838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183269.1 → NP_014627.1  TPA: Irc10p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014627.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W251, Q08118
      UniProtKB/TrEMBL
      A6ZNJ2, B3LJ42, C7GQW7, C8ZHU9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08118.1

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