RAP1 DNA-binding transcription factor RAP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RAP1
Official Full Name: DNA-binding transcription factor RAP1
Primary source: SGD:S000005160
Locus tag: YNL216W
See related: AllianceGenome:SGD:S000005160; FungiDB:YNL216W; VEuPathDB:YNL216W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GRC4; GRF1; TBA1; TUF1
Summary: Enables several functions, including DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and general transcription initiation factor binding activity. Involved in several processes, including establishment of protein localization to chromosome; regulation of nucleobase-containing compound metabolic process; and telomere organization. Located in chromosome, telomeric region; cytosol; and nuclear chromosome. Part of shelterin complex. Orthologous to human TERF2IP (TERF2 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RAP1 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (241689..244172)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Context-dependent function of the transcriptional regulator Rap1 in gene silencing and activation in Saccharomyces cerevisiae.
Title: Context-dependent function of the transcriptional regulator Rap1 in gene silencing and activation in Saccharomyces cerevisiae.
Rif2 protects Rap1-depleted telomeres from MRX-mediated degradation in Saccharomyces cerevisiae.
Title: Rif2 protects Rap1-depleted telomeres from MRX-mediated degradation in Saccharomyces cerevisiae.
Telomerase, the recombination machinery and Rap1 play redundant roles in yeast telomere protection.
Title: Telomerase, the recombination machinery and Rap1 play redundant roles in yeast telomere protection.
Budding yeast Rap1, but not telomeric DNA, is inhibitory for multiple stages of DNA replication in vitro.
Title: Budding yeast Rap1, but not telomeric DNA, is inhibitory for multiple stages of DNA replication in vitro.
Rap1-mediated nucleosome displacement can regulate gene expression in senescent cells without impacting the pace of senescence.
Title: Rap1-mediated nucleosome displacement can regulate gene expression in senescent cells without impacting the pace of senescence.
A Prion Epigenetic Switch Establishes an Active Chromatin State.
Title: A Prion Epigenetic Switch Establishes an Active Chromatin State.
Structural basis of G-quadruplex DNA recognition by Rap1.
Title: Structural basis of G-quadruplex DNA recognition by the yeast telomeric protein Rap1.
The rescue of fused telomeres results from a condensin- and Rap1-driven chromosome folding that favors fusion entrapment where abscission takes place.
Title: Condensin-Mediated Chromosome Folding and Internal Telomeres Drive Dicentric Severing by Cytokinesis.
REVIEW: Rap1 confers promoter directionality by repressing divergent transcription
Title: Transcribe this way: Rap1 confers promoter directionality by repressing divergent transcription.
Rap1 has an essential role in the fidelity of transcription initiation and in the suppression of pervasive transcription.
Title: General Regulatory Factors Control the Fidelity of Transcription by Restricting Non-coding and Ectopic Initiation.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding, bending	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables G-quadruplex DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
enables TBP-class protein binding	IDA Inferred from Direct Assay more info	PubMed
enables TFIID-class transcription factor complex binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleosomal DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	HDA more info	PubMed
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomeric DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables telomeric G-quadruplex DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G-quadruplex DNA formation	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of protein localization to chromatin	IPI Inferred from Physical Interaction more info	PubMed
involved_in establishment of protein localization to telomere	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protection from non-homologous end joining at telomere	IBA Inferred from Biological aspect of Ancestor more info
involved_in protection from non-homologous end joining at telomere	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glycolytic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in silent mating-type cassette heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in subtelomeric heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in subtelomeric heterochromatin formation	IPI Inferred from Physical Interaction more info	PubMed
involved_in telomere maintenance	IEA Inferred from Electronic Annotation more info
involved_in telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance via telomere lengthening	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via telomere lengthening	IDA Inferred from Direct Assay more info	PubMed
involved_in telomere maintenance via telomere lengthening	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of shelterin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of shelterin complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DNA-binding transcription factor RAP1

NP_014183.1

Essential DNA-binding transcription regulator that binds many loci; involved in transcription activation, repression, chromatin silencing, telomere length maintenance; represses divergent noncoding transcription at highly expressed genes, prevents transcription initiation at cryptic promoters near its binding sites; relocalizes to cytosol under hypoxia; recruits Sir complex to telomeric DNA; present in quiescent cell telomere hyperclusters

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

241689..244172

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183054.1 → NP_014183.1 TPA: DNA-binding transcription factor RAP1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014183.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0X4, P11938

UniProtKB/TrEMBL

A6ZRM4, B3LP60, C8ZG17, G2WLP7

Conserved Domains (4) summary

cd11653
Location:727 → 824

rap1_RCT; C-terminal domain of RAP1 recruits proteins to telomeres

cd11655
Location:360 → 413

rap1_myb-like; DNA-binding modules of yeast Rap1 and related proteins

pfam09197
Location:448 → 579

Rap1-DNA-bind; Rap1, DNA-binding

pfam16589
Location:127 → 207

BRCT_2; BRCT domain, a BRCA1 C-terminus domain