ASC1 ribosomal 40S subunit protein ASC1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ASC1
Official Full Name: ribosomal 40S subunit protein ASC1
Primary source: SGD:S000004722
Locus tag: YMR116C
See related: AllianceGenome:SGD:S000004722; FungiDB:YMR116C; VEuPathDB:YMR116C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ASU9; CPC2; NAD1
Summary: Enables G-protein alpha-subunit binding activity; GDP-dissociation inhibitor activity; and ribosome binding activity. Involved in several processes, including negative regulation of glucose mediated signaling pathway; nonfunctional rRNA decay; and post-transcriptional regulation of gene expression. Acts upstream of or within maintenance of translational fidelity. Part of cytosolic small ribosomal subunit. Is active in cytoplasm. Orthologous to human RACK1 (receptor for activated C kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ASC1 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 2

Sequence:: Chromosome: XIII; NC_001145.3 (499456..500688, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multi-omics analysis of glucose-mediated signaling by a moonlighting Gbeta protein Asc1/RACK1.
Title: Multi-omics analysis of glucose-mediated signaling by a moonlighting Gβ protein Asc1/RACK1.
Mbf1 and Rps3 cooperate to maintain the reading frame of stalled ribosomes, while Asc1 also mediates distinct events that result in recruitment of the ribosome quality control complex and mRNA decay.
Title: Multi-protein bridging factor 1(Mbf1), Rps3 and Asc1 prevent stalled ribosomes from frameshifting.
Data provide evidence that Asc1 seems to connect signal transduction not only with the translational machinery, but also with fundamental nuclear processes.
Title: Capturing the Asc1p/Receptor for Activated C Kinase 1 (RACK1) Microenvironment at the Head Region of the 40S Ribosome with Quantitative BioID in Yeast.
These indicate that ribosome-associated Asc1/RACK1 facilitates endonucleolytic cleavage of nonstop mRNA by stalled ribosomes and represses the levels of aberrant products even in the absence of Dom34. We propose that Asc1/RACK1 acts as a fail-safe in quality control for nonstop mRNA.
Title: Ribosome-associated Asc1/RACK1 is required for endonucleolytic cleavage induced by stalled ribosome at the 3' end of nonstop mRNA.
identify Asc1p (aka RACK1) and Rps3p, both stable 40S subunit components, as additional 18S nonfunctional 18S rRNA decay factors
Title: ASC1 and RPS3: new actors in 18S nonfunctional rRNA decay.
premature arrest at ribosome stalling sequences still occurred robustly in the absence of Asc1, Hel2, and Slh1. However, these three factors were required for the ribosome quality control complex to modify the nascent chain.
Title: Asc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation.
Translation fidelity depends upon Asc1-mediated quality control.
Title: Asc1, homolog of human RACK1, prevents frameshifting in yeast by ribosomes stalled at CGA codon repeats.
These results indicate the intertwined structure of a relatively small and stable protein core and the remaining regions of different levels of flexibility.
Title: Patterns of structural dynamics in RACK1 protein retained throughout evolution: a hydrogen-deuterium exchange study of three orthologs.
Genetic interactions between dys1-1 mutants and mutant PKC1 and ASC1, implicate a role for HYP2 (eIF5A homolog) and Asc1 in the maintenance of cell integrity at the translational level.
Title: The deoxyhypusine synthase mutant dys1-1 reveals the association of eIF5A and Asc1 with cell wall integrity.
Evidence of the translational regulation of such transcription factors suggests that ribosomal Asc1p is involved in signal transduction pathways and controls the biosynthesis of the respective final transcriptional regulators.
Title: RACK1/Asc1p, a ribosomal node in cellular signaling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables GDP-dissociation inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase C binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IDA Inferred from Direct Assay more info	PubMed
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables translation regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in mRNA destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maintenance of translational fidelity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glucose mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glucose mediated signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translational frameshifting	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of translational frameshifting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nonfunctional rRNA decay	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of amino acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rescue of stalled ribosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribosomal 40S subunit protein ASC1

NP_013834.1

G-protein beta subunit and guanine dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; required to prevent frameshifting at ribosomes stalled at repeated CGA codons; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation; controls phosphorylation of multiple proteins