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    MSC1 Msc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854911, updated on 27-Dec-2024

    Summary

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    Official Symbol
    MSC1
    Official Full Name
    Msc1p
    Primary source
    SGD:S000004597
    Locus tag
    YML128C
    See related
    AllianceGenome:SGD:S000004597; FungiDB:YML128C; VEuPathDB:YML128C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in reciprocal meiotic recombination. Acts upstream of or within protein localization to site of double-strand break. Located in mitochondrion. Is active in nuclear envelope. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MSC1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (15135..16676, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ER oxidoreductin Neighboring gene Cox14p Neighboring gene Rsc9p Neighboring gene hydroxymethylglutaryl-CoA synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Msc1 is a nuclear envelope protein that reinforces DNA repair in late mitosis. Medina-Suárez S, et al. iScience, 2024 Jul 19. PMID 39021806, Free PMC Article
    2. Stress response and expression patterns in wine fermentations of yeast genes induced at the diauxic shift. Puig S, et al. Yeast, 2000 Jan 30. PMID 10641036
    3. Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination. Thompson DA, et al. Genetics, 1999 Oct. PMID 10511544, Free PMC Article
    4. Yeast mitochondrial dehydrogenases are associated in a supramolecular complex. Grandier-Vazeille X, et al. Biochemistry, 2001 Aug 21. PMID 11502169
    5. Hsp104 disaggregase at normal levels cures many [PSI(+)] prion variants in a process promoted by Sti1p, Hsp90, and Sis1p. Gorkovskiy A, et al. Proc Natl Acad Sci U S A, 2017 May 23. PMID 28484020, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein localization to site of double-strand break IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    Msc1p
    NP_013578.1
    • Nuclear envelope protein involved in DSB repair during late mitosis; forms nuclear envelope patches associated with Rad52p-containing DNA repair foci, and accelerates homologous recombination downstream of DNA end resection; mutant is defective in directing meiotic recombination events to homologous chromatids; upregulated after DNA damage in late mitosis; null mutant is hypersensitive to DSBs; non-tagged protein is detected in highly purified mitochondria and is phosphorylated

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      15135..16676 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182491.1 → NP_013578.1  TPA: Msc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013578.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0F7, Q03104
      UniProtKB/TrEMBL
      B3LLD2, C8ZE74, N1NXS7
      Conserved Domains (1) summary
      pfam10281
      Location:109 → 145
      Ish1; Putative stress-responsive nuclear envelope protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03104.1

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