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    NMD4 Nmd4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851077, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NMD4
    Official Full Name
    Nmd4p
    Primary source
    SGD:S000004355
    Locus tag
    YLR363C
    See related
    AllianceGenome:SGD:S000004355; FungiDB:YLR363C; VEuPathDB:YLR363C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NMD4 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (852495..853151, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitogen-activated protein kinase kinase kinase STE11 Neighboring gene uncharacterized protein Neighboring gene glutathione-disulfide reductase GRX8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the Nmd4-Upf1 complex supports conservation of the nonsense-mediated mRNA decay pathway between yeast and humans. Barbarin-Bocahu I, et al. PLoS Biol, 2024 Sep. PMID 39331656, Free PMC Article
    2. Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. He F, et al. Genes Dev, 1995 Feb 15. PMID 7883168
    3. Nonsense-mediated decay regulates key components of homologous recombination. Janke R, et al. Nucleic Acids Res, 2016 Jun 20. PMID 27001511, Free PMC Article
    4. Interactions of subunit CCT3 in the yeast chaperonin CCT/TRiC with Q/N-rich proteins revealed by high-throughput microscopy analysis. Nadler-Holly M, et al. Proc Natl Acad Sci U S A, 2012 Nov 13. PMID 23112166, Free PMC Article
    5. An evolutionary proteomics approach identifies substrates of the cAMP-dependent protein kinase. Budovskaya YV, et al. Proc Natl Acad Sci U S A, 2005 Sep 27. PMID 16172400, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Nmd4p
    NP_013467.3
    • Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      852495..853151 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182252.3 → NP_013467.3  TPA: Nmd4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013467.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ01, Q12129
      UniProtKB/TrEMBL
      A7A1P1, B3RHN1, B5VNQ4, C7GRV8, C8ZDX1, G2WJI1, N1NZP9
      Conserved Domains (1) summary
      cd18717
      Location:7 → 155
      PIN_ScNmd4p-like; VapC-like PIN domain of Saccharomyces cerevisiae Nmd4p and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12129.1

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