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    CIN4 Arf family GTPase CIN4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855169, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CIN4
    Official Full Name
    Arf family GTPase CIN4
    Primary source
    SGD:S000004746
    Locus tag
    YMR138W
    See related
    AllianceGenome:SGD:S000004746; FungiDB:YMR138W; VEuPathDB:YMR138W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GTP1; UGX1
    Summary
    Predicted to enable GTP binding activity. Involved in protein folding and tubulin complex assembly. Located in cytoplasm. Orthologous to human ARL2 (ADP ribosylation factor like GTPase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CIN4 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (545155..545730)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Gat2p Neighboring gene DNA cross-link repair protein PSO2 Neighboring gene serine/threonine protein kinase RIM11 Neighboring gene Sip5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular structure of the DNA cross-link repair gene SNM1 (PSO2) of the yeast Saccharomyces cerevisiae. Richter D, et al. Mol Gen Genet, 1992 Jan. PMID 1736091
    2. Molecular characterisation of GTP1, a Saccharomyces cerevisiae gene encoding a small GTP-binding protein. Wolter R, et al. Curr Genet, 1994 Nov-Dec. PMID 7874754
    3. Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes. Hoyt MA, et al. Mol Cell Biol, 1990 Jan. PMID 2403635, Free PMC Article
    4. Improving Chromosome Synthesis with a Semiquantitative Phenotypic Assay and Refined Assembly Strategy. Lin Y, et al. ACS Synth Biol, 2019 Oct 18. PMID 31532633
    5. Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function. Stearns T, et al. Genetics, 1990 Feb. PMID 2407611, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tubulin complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tubulin complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Arf family GTPase CIN4
    NP_013858.1
    • GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      545155..545730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182640.1 → NP_013858.1  TPA: Arf family GTPase CIN4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013858.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZW1, P39110
      UniProtKB/TrEMBL
      A6ZMJ8, B3LM26, B5VPR6, C7GU80, C8ZEZ4, G2WKJ0, N1NYU5
      Conserved Domains (1) summary
      cl38936
      Location:3 → 187
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39110.1

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