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    BCH1 exomer complex subunit [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855277, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BCH1
    Official Full Name
    exomer complex subunit
    Primary source
    SGD:S000004850
    Locus tag
    YMR237W
    See related
    AllianceGenome:SGD:S000004850; FungiDB:YMR237W; VEuPathDB:YMR237W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables small GTPase binding activity. Involved in Golgi to plasma membrane transport and chitin biosynthetic process. Part of exomer complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BCH1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (743749..745923)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein RNA1 Neighboring gene chromatin modification protein Neighboring gene putative mannan endo-1,6-alpha-mannosidase Neighboring gene tRNA-Arg

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The exomer cargo adaptor features a flexible hinge domain. Richardson BC, et al. Structure, 2013 Mar 5. PMID 23395181, Free PMC Article
    2. Structural basis for membrane binding and remodeling by the exomer secretory vesicle cargo adaptor. Paczkowski JE, et al. Dev Cell, 2014 Sep 8. PMID 25203211, Free PMC Article
    3. The complex interactions of Chs5p, the ChAPs, and the cargo Chs3p. Rockenbauch U, et al. Mol Biol Cell, 2012 Nov. PMID 23015758, Free PMC Article
    4. Exomer: A coat complex for transport of select membrane proteins from the trans-Golgi network to the plasma membrane in yeast. Wang CW, et al. J Cell Biol, 2006 Sep 25. PMID 17000877, Free PMC Article
    5. The exomer coat complex transports Fus1p to the plasma membrane via a novel plasma membrane sorting signal in yeast. Barfield RM, et al. Mol Biol Cell, 2009 Dec. PMID 19812245, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Golgi to plasma membrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chitin biosynthetic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exomer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exomer complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exomer complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    exomer complex subunit
    NP_013964.1
    • Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; interacts selectively with the activated, GTP-bound form of Arf1p; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      743749..745923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182744.1 → NP_013964.1  TPA: exomer complex subunit [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013964.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W063, Q05029
      UniProtKB/TrEMBL
      C7GRB4, C8ZFA2, N1P0K7
      Conserved Domains (1) summary
      pfam09295
      Location:85 → 511
      ChAPs; ChAPs (Chs5p-Arf1p-binding proteins)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05029.1

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