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    DFG5 putative mannan endo-1,6-alpha-mannosidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855278, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DFG5
    Official Full Name
    putative mannan endo-1,6-alpha-mannosidase
    Primary source
    SGD:S000004851
    Locus tag
    YMR238W
    See related
    AllianceGenome:SGD:S000004851; FungiDB:YMR238W; VEuPathDB:YMR238W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable mannan endo-1,6-alpha-mannosidase activity. Involved in budding cell bud growth; fungal-type cell wall biogenesis; and pseudohyphal growth. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DFG5 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (746353..747729)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene chromatin modification protein Neighboring gene exomer complex subunit Neighboring gene tRNA-Arg Neighboring gene ribonuclease III

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two homologous genes, DCW1 (YKL046c) and DFG5, are essential for cell growth and encode glycosylphosphatidylinositol (GPI)-anchored membrane proteins required for cell wall biogenesis in Saccharomyces cerevisiae. Kitagaki H, et al. Mol Microbiol, 2002 Nov. PMID 12421307
    2. A temperature-sensitive dcw1 mutant of Saccharomyces cerevisiae is cell cycle arrested with small buds which have aberrant cell walls. Kitagaki H, et al. Eukaryot Cell, 2004 Oct. PMID 15470258, Free PMC Article
    3. Systematic genetic modifications of cell wall biosynthesis enhanced the secretion and surface-display of polysaccharide degrading enzymes in Saccharomyces cerevisiae. Chen N, et al. Metab Eng, 2023 May. PMID 37100192
    4. Signaling alkaline pH stress in the yeast Saccharomyces cerevisiae through the Wsc1 cell surface sensor and the Slt2 MAPK pathway. Serrano R, et al. J Biol Chem, 2006 Dec 29. PMID 17088254
    5. Loss of Dfg5 glycosylphosphatidylinositol-anchored membrane protein confers enhanced heat tolerance in Saccharomyces cerevisiae. Nasution O, et al. Environ Microbiol, 2015 Aug. PMID 25297926

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a model is proposed on the signal transduction pathways associated with deletion of DFG5 upon heat stress.
      Title: Loss of Dfg5 glycosylphosphatidylinositol-anchored membrane protein confers enhanced heat tolerance in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannan endo-1,6-alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in budding cell bud growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in budding cell bud growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in carbohydrate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fungal-type cell wall biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative mannan endo-1,6-alpha-mannosidase
    NP_013965.1
    • Putative mannosidase; essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      746353..747729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182745.1 → NP_013965.1  TPA: putative mannan endo-1,6-alpha-mannosidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013965.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W064, Q05031
      UniProtKB/TrEMBL
      A6ZMV1, B3LMC6, B5VQ07, C7GRB3, C8ZFA3, G2WKU6, N1NYP3
      Conserved Domains (1) summary
      pfam03663
      Location:36 → 385
      Glyco_hydro_76; Glycosyl hydrolase family 76
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05031.1

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