U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SAP30 Sap30p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855305, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SAP30
    Official Full Name
    Sap30p
    Primary source
    SGD:S000004876
    Locus tag
    YMR263W
    See related
    AllianceGenome:SGD:S000004876; FungiDB:YMR263W; VEuPathDB:YMR263W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables transcription corepressor activity. Involved in cellular response to heat; positive regulation of invasive growth in response to glucose limitation; and regulation of gene expression. Part of Rpd3L complex. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SAP30 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (794919..795524)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene trehalose 6-phosphate synthase/phosphatase complex subunit Neighboring gene putative endodeoxyribonuclease Neighboring gene Cue1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Pho23 is associated with the Rpd3 histone deacetylase and is required for its normal function in regulation of gene expression and silencing in Saccharomyces cerevisiae. Loewith R, et al. J Biol Chem, 2001 Jun 29. PMID 11306585
    2. Raf60, a novel component of the Rpd3 histone deacetylase complex required for Rpd3 activity in Saccharomyces cerevisiae. Colina AR, et al. J Biol Chem, 2005 Dec 30. PMID 16275642
    3. A promiscuous prion: efficient induction of [URE3] prion formation by heterologous prion domains. Ross CD, et al. Genetics, 2009 Nov. PMID 19752212, Free PMC Article
    4. The Yeast Prion [SWI(+)] Abolishes Multicellular Growth by Triggering Conformational Changes of Multiple Regulators Required for Flocculin Gene Expression. Du Z, et al. Cell Rep, 2015 Dec 29. PMID 26711350, Free PMC Article
    5. Identification of novel genes involved in neutral lipid storage by quantitative trait loci analysis of Saccharomyces cerevisiae. Pačnik K, et al. BMC Genomics, 2021 Feb 9. PMID 33563210, Free PMC Article

    See all (128) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of rDNA heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of silent mating-type cassette heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of invasive growth in response to glucose limitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Rpd3L complex HDA PubMed 
    part_of Rpd3L complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rpd3L-Expanded complex HDA PubMed 
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Sap30p
    NP_013990.1
    • Component of Rpd3L histone deacetylase complex; involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      794919..795524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182770.1 → NP_013990.1  TPA: Sap30p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013990.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W089, P38429, Q03501
      UniProtKB/TrEMBL
      A6ZMX8, B3LMF0, B5VQ28, C7GR90, C8ZFC9, N1NXP9
      Conserved Domains (1) summary
      pfam13867
      Location:110 → 186
      SAP30_Sin3_bdg; Sin3 binding region of histone deacetylase complex subunit SAP30
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38429.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.