PFS2 cleavage polyadenylation factor subunit PFS2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PFS2
Official Full Name: cleavage polyadenylation factor subunit PFS2
Primary source: SGD:S000005261
Locus tag: YNL317W
See related: AllianceGenome:SGD:S000005261; FungiDB:YNL317W; VEuPathDB:YNL317W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to contribute to RNA binding activity. Involved in mRNA processing. Part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human WDR33 (WD repeat domain 33). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PFS2 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (40619..42016)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Authors present genetic evidence for an essential role of the GINS complex (comprising the Psf1, Psf2, Psf3 and Sld5 subunits) in the maintenance of replication fidelity in Saccharomyces cerevisiae.
Title: Proper functioning of the GINS complex is important for the fidelity of DNA replication in yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to RNA binding	IC Inferred by Curator more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA 3'-end processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mRNA cleavage and polyadenylation specificity factor complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cleavage polyadenylation factor subunit PFS2

NP_014082.1

Integral subunit of the pre-mRNA CPF complex; the cleavage and polyadenylation factor (CPF) complex plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

40619..42016

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183155.1 → NP_014082.1 TPA: cleavage polyadenylation factor subunit PFS2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014082.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0M8, P42841, Q6B1M2

UniProtKB/TrEMBL

A6ZSG3, B3LPF1, B5VQA3, C7GWR4, C8ZGK8, G2WLF2, N1NZ89

Conserved Domains (2) summary

cd00200
Location:93 → 377

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:98 → 133

7WD40; WD40 repeat [structural motif]