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    Parp16 Poly(ADP-ribose) polymerase 16 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36841, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Parp16provided by FlyBase
    Official Full Name
    Poly(ADP-ribose) polymerase 16provided by FlyBase
    Primary source
    FLYBASE:FBgn0034129
    Locus tag
    Dmel_CG15925
    See related
    AllianceGenome:FB:FBgn0034129
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15925; dARTD15; Dmel\CG15925; dPARP16
    Summary
    Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity; kinase binding activity; and protein serine/threonine kinase activator activity. Predicted to be involved in endoplasmic reticulum unfolded protein response. Predicted to be active in endoplasmic reticulum tubular network and nuclear envelope. Orthologous to human PARP16 (poly(ADP-ribose) polymerase family member 16). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Parp16 in Genome Data Viewer
    Location:
    53C4-53C5; 2-80 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16445986..16447512)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12333491..12335017)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Chemosensory protein B 53a Neighboring gene Chemosensory protein B 53b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo vizualisation of mono-ADP-ribosylation by dPARP16 upon amino-acid starvation. Aguilera-Gomez A, et al. Elife, 2016 Nov 22. PMID 27874829, Free PMC Article
    2. Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Kwon M, et al. Genes Dev, 2008 Aug 15. PMID 18662975, Free PMC Article
    3. Lack of global meiotic sex chromosome inactivation, and paucity of tissue-specific gene expression on the Drosophila X chromosome. Mikhaylova LM, et al. BMC Biol, 2011 May 4. PMID 21542906, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD+-protein poly-ADP-ribosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum tubular network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Poly(ADP-ribose) polymerase 16
    Names
    CG15925-PA
    Parp16-PA
    Poly(ADP-ribose) polymerase family member 16
    NP_725583.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16445986..16447512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166177.3 → NP_725583.1  Poly(ADP-ribose) polymerase 16 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725583.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZAG4, Q8T910
      Related
      FBpp0086303
      Conserved Domains (1) summary
      pfam18084
      Location:53 → 132
      ARTD15_N; ARTD15 N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAG4.1 A1ZAG4

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