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    LAG2 Lag2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854133, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LAG2
    Official Full Name
    Lag2p
    Primary source
    SGD:S000005385
    Locus tag
    YOL025W
    See related
    AllianceGenome:SGD:S000005385; FungiDB:YOL025W; VEuPathDB:YOL025W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ECM36
    Summary
    Involved in negative regulation of protein ubiquitination. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LAG2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (274957..276939)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Mim1p Neighboring gene tRNA-Ser Neighboring gene uncharacterized protein Neighboring gene translation initiation factor 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LAG2, a gene that determines yeast longevity. Childress AM, et al. Microbiology (Reading), 1996 Aug. PMID 8760941
    2. Aging in Saccharomyces cerevisiae. Sinclair D, et al. Annu Rev Microbiol, 1998. PMID 9891807
    3. A synthetic lethal screen identifies HDAC4 as a potential target in MELK overexpressing cancers. Zhou L, et al. G3 (Bethesda), 2021 Dec 8. PMID 34550356, Free PMC Article
    4. CSN- and CAND1-dependent remodelling of the budding yeast SCF complex. Zemla A, et al. Nat Commun, 2013. PMID 23535662
    5. Analysis of the DNA sequence of a 34,038 bp region on the left arm of yeast chromosome XV. Rad MR, et al. Yeast, 1997 Mar 15. PMID 9090058

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. binding of substrate-specific adaptors triggers release of Cand1/Lag2, whereas subsequent neddylation of the cullin facilitates the removal and prevents re-association of Lag2/Cand1
      Title: Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae.
    2. Lag2 disrupts the ubiquitylation activity of the SCF E3 ligase by interrupting the association of Cdc34 to SCF complex.
      Title: A longevity protein, Lag2, interacts with SCF complex and regulates SCF function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of protein ubiquitination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Lag2p
    NP_014617.1
    • Protein that negatively regulates the SCF E3-ubiquitin ligase; regulates by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      274957..276939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183279.1 → NP_014617.1  TPA: Lag2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014617.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W240, Q08175, Q92325
      UniProtKB/TrEMBL
      B3LJ32, C7GJZ6, C8ZHT8, N1NWD3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92325.2

    Gene LinkOut

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