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    pyridoxal 5'-phosphate synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856302, updated on 9-Dec-2024

    Summary

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    Official Full Name
    pyridoxal 5'-phosphate synthase
    Primary source
    SGD:S000006376
    Locus tag
    YPR172W
    See related
    AllianceGenome:SGD:S000006376; FungiDB:YPR172W; VEuPathDB:YPR172W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (885796..886398)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Bsp1p Neighboring gene AAA family ATPase VPS4 Neighboring gene Csa1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Competitive promoter occupancy by two yeast paralogous transcription factors controlling the multidrug resistance phenomenon. Lucau-Danila A, et al. J Biol Chem, 2003 Dec 26. PMID 14512416
    2. Endosome and Golgi-associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism. Schmidt O, et al. EMBO J, 2019 Aug 1. PMID 31368600, Free PMC Article
    3. The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces cerevisiae. Josefson R, et al. Sci Rep, 2023 Jun 7. PMID 37286562, Free PMC Article
    4. Global analysis of SUMO chain function reveals multiple roles in chromatin regulation. Srikumar T, et al. J Cell Biol, 2013 Apr 1. PMID 23547032, Free PMC Article
    5. Subcellular localization of the yeast proteome. Kumar A, et al. Genes Dev, 2002 Mar 15. PMID 11914276, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. does not function as a pyridoxamine 5'-phosphate oxidase
      Title: Experimental Evidence for a Revision in the Annotation of Putative Pyridoxamine 5'-Phosphate Oxidases P(N/M)P from Fungi.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pyridoxal 5'-phosphate synthase
    NP_015498.1
    • hypothetical protein; predicted to encode a pyridoxal 5'-phosphate synthase based on sequence similarity but purified protein does not possess this activity, nor does it bind flavin mononucleotide (FMN); transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      885796..886398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184269.1 → NP_015498.1  TPA: pyridoxal 5'-phosphate synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015498.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4H3, Q06608
      UniProtKB/TrEMBL
      B3LKD2, B5VTV4, C8ZJK1, N1NXV5
      Conserved Domains (1) summary
      pfam01243
      Location:7 → 85
      Putative_PNPOx; Pyridoxamine 5'-phosphate oxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06608.1

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