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    uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850449, updated on 9-Dec-2024

    Summary

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    Official Full Name
    uncharacterized protein
    Primary source
    SGD:S000007223
    Locus tag
    YCR087C-A
    See related
    AllianceGenome:SGD:S000007223; FungiDB:YCR087C-A; VEuPathDB:YCR087C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and rRNA processing. Located in nucleolus. Orthologous to human LYAR (Ly1 antibody reactive). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (264006..264467, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Csm1p Neighboring gene Abp1p Neighboring gene Fig2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hermes Transposon Mutagenesis Shows [URE3] Prion Pathology Prevented by a Ubiquitin-Targeting Protein: Evidence for Carbon/Nitrogen Assimilation Cross Talk and a Second Function for Ure2p in Saccharomyces cerevisiae. Edskes HK, et al. Genetics, 2018 Jul. PMID 29769283, Free PMC Article
    2. Reverse recruitment: the Nup84 nuclear pore subcomplex mediates Rap1/Gcr1/Gcr2 transcriptional activation. Menon BB, et al. Proc Natl Acad Sci U S A, 2005 Apr 19. PMID 15817685, Free PMC Article
    3. Two novel effectors of trafficking and maturation of the yeast plasma membrane H(+) -ATPase. Geva Y, et al. Traffic, 2017 Oct. PMID 28727280, Free PMC Article
    4. The ribosome assembly factor Nop53 controls association of the RNA exosome with pre-60S particles in yeast. Cepeda LPP, et al. J Biol Chem, 2019 Dec 13. PMID 31662437, Free PMC Article
    5. Heme, A Metabolic Sensor, Directly Regulates the Activity of the KDM4 Histone Demethylase Family and Their Interactions with Partner Proteins. Konduri PC, et al. Cells, 2020 Mar 22. PMID 32235736, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_010011.1
    • hypothetical protein; binds zinc; phosphomutants exhibit phenotypes, suggesting functionality of phosphosites; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      264006..264467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184316.1 → NP_010011.1  TPA: uncharacterized protein YCR087C-A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010011.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR87, P37263
      UniProtKB/TrEMBL
      G2WA94, N1P974
      Conserved Domains (1) summary
      pfam08790
      Location:30 → 58
      zf-LYAR; LYAR-type C2HC zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37263.1

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