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    VPS54 Vps54p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851591, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VPS54
    Official Full Name
    Vps54p
    Primary source
    SGD:S000002434
    Locus tag
    YDR027C
    See related
    AllianceGenome:SGD:S000002434; FungiDB:YDR027C; VEuPathDB:YDR027C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CGP1; LUV1; TCS3
    Summary
    Predicted to enable syntaxin binding activity. Involved in several processes, including Golgi to vacuole transport; ascospore wall assembly; and intracellular sphingolipid homeostasis. Located in Golgi apparatus. Part of GARP complex. Orthologous to human VPS54 (VPS54 subunit of GARP complex). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VPS54 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (494649..497318, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S11A Neighboring gene Nsi1p Neighboring gene protein phosphatase regulator REG1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Luv1p/Rki1p/Tcs3p/Vps54p, a yeast protein that localizes to the late Golgi and early endosome, is required for normal vacuolar morphology. Conboy MJ, et al. Mol Biol Cell, 2000 Jul. PMID 10888679, Free PMC Article
    2. Regulation of tubulin polypeptides and microtubule function: Luv1p [correction of Rki1p] interacts with the beta-tubulin binding protein Rbl2p. Smith AM, et al. Chromosoma, 1998 Dec. PMID 9914379
    3. Domains within the GARP subunit Vps54 confer separate functions in complex assembly and early endosome recognition. Quenneville NR, et al. Mol Biol Cell, 2006 Apr. PMID 16452629, Free PMC Article
    4. Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation. Bryant NJ, et al. EMBO J, 2001 Jul 2. PMID 11432826, Free PMC Article
    5. Identification, characterization and cytogenetic mapping of a yeast Vps54 homolog in rat and mouse. Walter L, et al. Gene, 2002 Feb 20. PMID 12039048

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ascospore wall assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular sphingolipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GARP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GARP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of GARP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vps54p
    NP_010310.1
    • Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; potentially phosphorylated by Cdc28p; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      494649..497318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180335.1 → NP_010310.1  TPA: Vps54p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010310.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS12, Q12071
      UniProtKB/TrEMBL
      A6ZXZ0, B3LGN8, C7GLX0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12071.1

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