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    DIC1 Dic1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851063, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DIC1
    Official Full Name
    Dic1p
    Primary source
    SGD:S000004340
    Locus tag
    YLR348C
    See related
    AllianceGenome:SGD:S000004340; FungiDB:YLR348C; VEuPathDB:YLR348C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables dicarboxylic acid transmembrane transporter activity. Involved in dicarboxylic acid transport. Located in mitochondrial envelope. Used to study mitochondrial DNA depletion syndrome; mitochondrial complex I deficiency; and myoclonic-atonic epilepsy. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 19. Orthologous to human SLC25A10 (solute carrier family 25 member 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DIC1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (826977..827873, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Cis1p Neighboring gene karyopherin beta Neighboring gene sphingolipid homeostasis protein ORM2 Neighboring gene putative hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization, purification and properties of the yeast mitochondrial dicarboxylate carrier (Saccharomyces cerevisiae). Lançar-Benba J, et al. Biochimie, 1996. PMID 8831951
    2. Identification of a novel gene encoding the yeast mitochondrial dicarboxylate transport protein via overexpression, purification, and characterization of its protein product. Kakhniashvili D, et al. J Biol Chem, 1997 Feb 14. PMID 9020177
    3. The mitochondrial dicarboxylate carrier is essential for the growth of Saccharomyces cerevisiae on ethanol or acetate as the sole carbon source. Palmieri L, et al. Mol Microbiol, 1999 Jan. PMID 10027973
    4. Topography of the active site of the Saccharomyces cerevisiae plasmalemmal dicarboxylate transporter studied using lipophilic derivatives of its substrates. Aliverdieva DA, et al. Biochemistry (Mosc), 2007 Mar. PMID 17447879
    5. Biogenesis of yeast dicarboxylate carrier: the carrier signature facilitates translocation across the mitochondrial outer membrane. Zara V, et al. J Cell Sci, 2007 Dec 1. PMID 18032784

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. each module of the dicarboxylate carrier contains sufficient targeting information for its transport across the outer mitochondrial membrane
      Title: The carboxyl-terminal third of the dicarboxylate carrier is crucial for productive association with the inner membrane twin-pore translocase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dicarboxylic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dicarboxylic acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables malate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxaloacetate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiosulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dicarboxylic acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in malate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oxaloacetate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oxaloacetate(2-) transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in succinate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thiosulfate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dic1p
    NP_013452.1
    • Mitochondrial dicarboxylate carrier; integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      826977..827873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182237.1 → NP_013452.1  TPA: Dic1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013452.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYY7, P87332, Q06143
      UniProtKB/TrEMBL
      A7A1M7, B3RHL8, C7GRX4, C8ZDV6, G2WJG7, N1NZN7
      Conserved Domains (1) summary
      pfam00153
      Location:20 → 94
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06143.1

    Gene LinkOut

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