ILV2 acetolactate synthase catalytic subunit [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ILV2
Official Full Name: acetolactate synthase catalytic subunit
Primary source: SGD:S000004714
Locus tag: YMR108W
See related: AllianceGenome:SGD:S000004714; FungiDB:YMR108W; VEuPathDB:YMR108W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SMR1; THI1
Summary: Enables acetolactate synthase activity and flavin adenine dinucleotide binding activity. Involved in branched-chain amino acid biosynthetic process. Located in mitochondrion. Part of acetolactate synthase complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ILV2 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (484084..486147)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Using various soluble quinone derivatives (e.g. ubiquinones), this study reveals a new path of down-regulation of acetolactate synthase activity involving inhibition by oxidized redox-signaling molecules.
Title: The Role of a FAD Cofactor in the Regulation of Acetohydroxyacid Synthase by Redox Signaling Molecules.
Data show that the pyruvate-forming enzyme Pyk1 was tethered to heterologous pyruvate-converting enzymes, lactate dehydrogenase and alpha-acetolactate synthase, to producelactic acid and 2,3-butanediol, respectively.
Title: Redirection of pyruvate flux toward desired metabolic pathways through substrate channeling between pyruvate kinase and pyruvate-converting enzymes in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables acetolactate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetolactate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetolactate synthase activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IDA Inferred from Direct Assay more info	PubMed
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables thiamine pyrophosphate binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-valine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-valine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in branched-chain amino acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in branched-chain amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in branched-chain amino acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in isoleucine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in isoleucine biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of acetolactate synthase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of acetolactate synthase complex	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acetolactate synthase catalytic subunit

NP_013826.1

EC 2.2.1.6

Acetolactate synthase; catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

484084..486147

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182608.1 → NP_013826.1 TPA: acetolactate synthase catalytic subunit [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013826.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZT1, P07342

UniProtKB/TrEMBL

A6ZMG5, B5VPN3, C7GWA1, C8ZEW1, G2WKF6, N1NXC1

Conserved Domains (1) summary

TIGR00118
Location:92 → 668

acolac_lg; acetolactate synthase, large subunit, biosynthetic type