Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp4b1provided by RGD
Official Full Name: cytochrome P450, family 4, subfamily b, polypeptide 1provided by RGD
Primary source: RGD:2480
See related: EnsemblRapid:ENSRNOG00000055078 AllianceGenome:RGD:2480
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables heterocyclic compound binding activity. Involved in biphenyl metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human CYP4B1 (cytochrome P450 family 4 subfamily B member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 940.3), Kidney (RPKM 160.3) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q35

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (134375807..134413635, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (129139019..129176860, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (134508728..134526103, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Examination of high-power photomicrographs suggests that CYP4B1 may be a secreted protein, based on the fact that immunoreactivity appears to be present in the lumens of ducts of Bowman's glands and in secretory granules in respiratory mucosa.
Title: Localization of CYP4B1 in the rat nasal cavity and analysis of CYPs as secreted proteins.

Submit: New GeneRIF Correction

General gene information

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Markers

D5Rat200 (e-PCR), detects polymorphism
- UniSTS:227899

RH137159 (e-PCR)
- UniSTS:219247

RH142421 (e-PCR)
- UniSTS:231668

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heterocyclic compound binding	IPI Inferred from Physical Interaction more info	PubMed
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	TAS Traceable Author Statement more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biphenyl metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 4B1

Names: CYPIVB1; P450 L-2; P450-isozyme 5; cytochrome P450 L-2; cytochrome P450 isozyme 5; cytochrome P450, subfamily 4B, polypeptide 1

NP_058695.2

EC 1.14.14.1

XP_038965183.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016999.2 → NP_058695.2 cytochrome P450 4B1

See identical proteins and their annotated locations for NP_058695.2

Status: PROVISIONAL

Source sequence(s)

M29853

UniProtKB/Swiss-Prot

P15129

UniProtKB/TrEMBL

A6JZ44

Related

ENSRNOP00000013321.5, ENSRNOT00000013321.8

Conserved Domains (1) summary

cd20678
Location:67 → 501

CYP4B-like; cytochrome P450 family 4, subfamily B and similar cytochrome P450s, including subfamilies A, T, X, and Z

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

134375807..134413635 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109255.2 → XP_038965183.1 cytochrome P450 4B1 isoform X1

Conserved Domains (1) summary

cl41757
Location:1 → 339

cytochrome_P450; cytochrome P450 (CYP) superfamily