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    Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266674, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cyp4a8provided by RGD
    Official Full Name
    cytochrome P450, family 4, subfamily a, polypeptide 8provided by RGD
    Primary source
    RGD:628846
    See related
    EnsemblRapid:ENSRNOG00000008842 AllianceGenome:RGD:628846
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cyp4a12
    Summary
    Enables fatty acid omega-hydroxylase activity. Involved in fatty acid metabolic process; kidney development; and response to testosterone. Located in endoplasmic reticulum membrane. Biomarker of autosomal recessive polycystic kidney disease and hypertension. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11) and CYP4A22 (cytochrome P450 family 4 subfamily A member 22). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 662.9) See more
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    Genomic context

    See Cyp4a8 in Genome Data Viewer
    Location:
    5q35
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (133938882..133970226, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (128702130..128733476, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (133978953..134008255, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 66 Neighboring gene cytochrome P450, family 4, subfamily x, polypeptide 1 Neighboring gene MCTS1, re-initiation and release factor, pseudogene 1 Neighboring gene cytochrome P450, family 4, subfamily a, polypeptide 8, pseudogene 1 Neighboring gene pyruvate kinase M1/2, pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC93354

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alkane 1-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables arachidonate monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables arachidonate omega-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fatty acid omega-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in arachidonate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in icosanoid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in kidney development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in kidney development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in lauric acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lauric acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in linoleic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to testosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    cytochrome P450 4A12
    Names
    CYPIVA12
    CYPIVA8
    P450-KP1
    P450-PP1
    cytochrome P450, 4a12
    cytochrome P450-KP1
    cytochrome P450-PP1
    NP_113793.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031605.2NP_113793.2  cytochrome P450 4A12

      See identical proteins and their annotated locations for NP_113793.2

      Status: PROVISIONAL

      Source sequence(s)
      BC081771
      UniProtKB/Swiss-Prot
      P24464, Q642E9
      Related
      ENSRNOP00000012448.4, ENSRNOT00000012448.7
      Conserved Domains (1) summary
      pfam00067
      Location:52503
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      133938882..133970226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)