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    Padi2 peptidyl arginine deiminase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29511, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Padi2provided by RGD
    Official Full Name
    peptidyl arginine deiminase 2provided by RGD
    Primary source
    RGD:3288
    See related
    EnsemblRapid:ENSRNOG00000007574 AllianceGenome:RGD:3288
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pdi2
    Summary
    Enables protein-arginine deiminase activity. Predicted to be involved in several processes, including estrogen receptor signaling pathway; substantia nigra development; and transcription initiation-coupled chromatin remodeling. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in euchromatin. Predicted to be active in cytoplasm and nucleus. Orthologous to human PADI2 (peptidyl arginine deiminase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 204.5), Brain (RPKM 97.1) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Padi2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (158492087..158534662)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (153209053..153251632)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (159428479..159471113)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene peptidyl arginine deiminase 1 Neighboring gene transfer RNA alanine (anticodon GGC) 1 Neighboring gene uncharacterized LOC102546642 Neighboring gene succinate dehydrogenase complex iron sulfur subunit B Neighboring gene ATPase cation transporting 13A2 Neighboring gene microfibril associated protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Increased expression of PAD2 after repeated intracerebroventricular infusions of soluble Abeta(25-35) in the Alzheimer's disease model rat brain: effect of memantine. Arif M, et al. Cell Mol Biol Lett, 2009. PMID 19641855, Free PMC Article
    2. Mechanical stretching elevates peptidyl arginine deiminase 2 expression in astrocytes. Algeciras ME, et al. Curr Eye Res, 2008 Nov. PMID 19085382, Free PMC Article
    3. Age-related reduction in retinal deimination levels in the F344BN rat. Bhattacharya SK, et al. Aging Cell, 2008 Jun. PMID 18248664, Free PMC Article
    4. Microglial expression of peptidylarginine deiminase 2 in the prenatal rat brain. Asaga H, et al. Cell Mol Biol Lett, 2007. PMID 17579814, Free PMC Article
    5. The rat peptidylarginine deiminase-encoding gene: structural analysis and the 5'-flanking sequence. Watanabe K, et al. Gene, 1992 May 15. PMID 1601308

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These biochemical and immunohistochemical results suggest that PAD2 might play an important role in the pathology of early Alzheimer's disease
      Title: Increased expression of PAD2 after repeated intracerebroventricular infusions of soluble Abeta(25-35) in the Alzheimer's disease model rat brain: effect of memantine.
    2. Mechanical stretching induced PAD2 expression and consequent protein deimination.
      Title: Mechanical stretching elevates peptidyl arginine deiminase 2 expression in astrocytes.
    3. The reduced levels of deimination commensurate with reduced protein, mRNA and activity of peptidylarginine deiminase type 2 in the retina.
      Title: Age-related reduction in retinal deimination levels in the F344BN rat.
    4. This report revealed the expression of PAD2 by microglia in the prenatal cerebrum at embryonic stages E19-E21.
      Title: Microglial expression of peptidylarginine deiminase 2 in the prenatal rat brain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H1R54 arginine deiminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AR3 arginine deiminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3R17 arginine deiminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3R2 arginine deiminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3R26 arginine deiminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3R26 arginine deiminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3R8 arginine deiminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4R3 arginine deiminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone arginine deiminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear estrogen receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-arginine deiminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-arginine deiminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in estrogen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of chemokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of lymphocyte chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of lymphocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in substantia nigra development ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in transcription initiation-coupled chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in euchromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein-arginine deiminase type-2
    Names
    peptidyl arginine deiminase, type 2
    peptidyl arginine deiminase, type II
    peptidylarginine deiminase II
    protein-arginine deiminase type II
    NP_058922.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017226.2 → NP_058922.2  protein-arginine deiminase type-2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P20717
      UniProtKB/TrEMBL
      A6ITP8
      Related
      ENSRNOP00000010183.6, ENSRNOT00000010183.7
      Conserved Domains (3) summary
      pfam03068
      Location:287 → 662
      PAD; Protein-arginine deiminase (PAD)
      pfam08526
      Location:1 → 114
      PAD_N; Protein-arginine deiminase (PAD) N-terminal domain
      pfam08527
      Location:116 → 274
      PAD_M; Protein-arginine deiminase (PAD) middle domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      158492087..158534662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20717.1 GenPept UniProtKB/Swiss-Prot:P20717

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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