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    MTR10 Mtr10p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854331, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MTR10
    Official Full Name
    Mtr10p
    Primary source
    SGD:S000005686
    Locus tag
    YOR160W
    See related
    AllianceGenome:SGD:S000005686; FungiDB:YOR160W; VEuPathDB:YOR160W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KAP111
    Summary
    Enables nuclear localization sequence binding activity. Involved in protein import into nucleus; snRNA import into nucleus; and tRNA import into nucleus. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 2. Orthologous to human TNPO3 (transportin 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MTR10 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (633839..636757)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein PET123 Neighboring gene mRNA splicing protein SME1 Neighboring gene Pns1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biogenesis of yeast telomerase depends on the importin mtr10. Ferrezuelo F, et al. Mol Cell Biol, 2002 Sep. PMID 12167699, Free PMC Article
    2. Retrograde movement of tRNAs from the cytoplasm to the nucleus in Saccharomyces cerevisiae. Shaheen HH, et al. Proc Natl Acad Sci U S A, 2005 Aug 9. PMID 16040803, Free PMC Article
    3. Identification of Gbp2 as a novel poly(A)+ RNA-binding protein involved in the cytoplasmic delivery of messenger RNAs in yeast. Windgassen M, et al. EMBO Rep, 2003 Mar. PMID 12634846, Free PMC Article
    4. Importin-beta family members mediate alpharetrovirus gag nuclear entry via interactions with matrix and nucleocapsid. Butterfield-Gerson KL, et al. J Virol, 2006 Feb. PMID 16439536, Free PMC Article
    5. Genome-wide investigation of the role of the tRNA nuclear-cytoplasmic trafficking pathway in regulation of the yeast Saccharomyces cerevisiae transcriptome and proteome. Chu HY, et al. Mol Cell Biol, 2013 Nov. PMID 23979602, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Npl3p, Gbp2p, and Hrb1p are part of the S. cerevisiae translating mRNPs, and Npl3p is regulated by Mtr10p and can function as a translational repressor
      Title: Yeast shuttling SR proteins Npl3p, Gbp2p, and Hrb1p are part of the translating mRNPs, and Npl3p can function as a translational repressor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nuclear localization sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in RNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear periphery HDA PubMed 
    located_in nuclear periphery HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mtr10p
    NP_014803.1
    • Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      633839..636757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183579.1 → NP_014803.1  TPA: Mtr10p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014803.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2L7, Q99189
      UniProtKB/TrEMBL
      A6ZP04, N1P395
      Conserved Domains (2) summary
      smart00913
      Location:28 → 97
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:100 → 253
      Xpo1; Exportin 1-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99189.1

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