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    Rps6ka4 ribosomal protein S6 kinase A4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361715, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rps6ka4provided by RGD
    Official Full Name
    ribosomal protein S6 kinase A4provided by RGD
    Primary source
    RGD:1307277
    See related
    EnsemblRapid:ENSRNOG00000021117 AllianceGenome:RGD:1307277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc88b
    Summary
    Predicted to enable ATP binding activity; histone H3S10 kinase activity; and histone H3S28 kinase activity. Predicted to be involved in several processes, including TORC1 signaling; interleukin-1-mediated signaling pathway; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm; nucleoplasm; and synapse. Orthologous to human RPS6KA4 (ribosomal protein S6 kinase A4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 65.9), Lung (RPKM 62.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rps6ka4 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213451026..213461982, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (204021805..204032781, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222087328..222098284, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 12 Neighboring gene PRELI domain containing 1, pseudogene 5 Neighboring gene coiled-coil domain containing 88B Neighboring gene uncharacterized LOC134483961

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB). Tomás-Zuber M, et al. J Biol Chem, 2001 Feb 23. PMID 11035004
    2. RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK). Pierrat B, et al. J Biol Chem, 1998 Nov 6. PMID 9792677
    3. MAPKAP kinases - MKs - two's company, three's a crowd. Gaestel M. Nat Rev Mol Cell Biol, 2006 Feb. PMID 16421520
    4. MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. Soloaga A, et al. EMBO J, 2003 Jun 2. PMID 12773393, Free PMC Article
    5. Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription. Wang B, et al. Arterioscler Thromb Vasc Biol, 2010 Mar. PMID 20018936

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3S28 kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-translational protein modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein S6 kinase alpha-4
    Names
    coiled-coil domain containing 88B
    ribosomal protein S6 kinase, polypeptide 4
    NP_001101987.2
    XP_038939947.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108517.2 → NP_001101987.2  ribosomal protein S6 kinase alpha-4

      Status: VALIDATED

      Source sequence(s)
      AW251264, BF407559, BQ194971, BU671341, CB700259, CB737401, DN932052, FM035808, FM059731
      UniProtKB/TrEMBL
      A6HZI4, D3ZSB7
      Related
      ENSRNOP00000028678.6, ENSRNOT00000028678.9
      Conserved Domains (2) summary
      cd05614
      Location:32 → 364
      STKc_MSK2_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2
      cl21453
      Location:404 → 714
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      213451026..213461982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084019.2 → XP_038939947.1  ribosomal protein S6 kinase alpha-4 isoform X1

      UniProtKB/TrEMBL
      A6HZI4
      Conserved Domains (1) summary
      cl21453
      Location:1 → 301
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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